Skip to main content

Table 1 List of substrates used as carbon source, respective metabolic pathways and genes coding for enzymes catalyzing the substrates

From: Identifying feasible metabolic routes in Mycobacterium smegmatis and possible alterations under diverse nutrient conditions

Source

Source type and metabolic pathways

Gene locus

Enzyme catalyzing substrate utilization

L-Proline

Aminoacid, TCA, oxologlutarate, Glu

0943, 1413, 2681

pyrroline-5-carboxylate reductase, ornithine-oxo-acid transaminase, proline imino-peptidase

D-Xylose

Carbohydrate, Pentose and glucuronate interconversions

6021

xylose isomerase

D- Mannitol

Carbohydrate, Glycolysis, fructose, mannose

5576

D-mannonate oxidoreductase

L-Rhamnose

Carbohydrate, Glycolysis, fructose, mannose

0589

L-rhamnose isomerase

D- Fructose

Carbohydrate, Glycolysis, fructose

3094 , 0085

oxidoreductase, zinc-binding dehydrogenase, PTS system, Fru family protein, IIABC components

Alpha- D Glucose

Carbohydrate, Glycolysis

2136, 1363

Phosphogluco mutase, glucokinase

L-Arabinose

Carbohydrate, Glycolysis, G3P, Pentose and glucuronate interconversions

1675

L-arabinose isomerase

D-Saccharic acid

Carbohydrate, Glycolysis Ascorbate and aldarate

6117, 0455

Glucarate dehydratase, aldehyde dehydrogenase

Succinic acid

Carboxylate, TCA

5524 , 5525, 0417, 0418

succinyl-CoA synthetase subunit alpha and beta

D-Mannose

Carbohydrate, Glycolysis, fructose, mannose

1834

Phosphomanno mutase/phosphogluco mutase

D-Sorbitol

Carbohydrate, Glycolysis, mannose

3094, 3605

oxidoreductase, zinc-binding dehydrogenase, sorbitol dehydrogenase

Glycerol

Carbohydrate, Glycolysis, glycerate

6229

glycerol kinase

D-Gluconic Acid

Carbohydrate, Glycolysis

1274, 0453

gluconolactonase, shikimate kinase

L-Lactic acid

Carboxylate

2512

lactate 2-monooxygenase

D-Galactonic acid - gamma -Lactone

Carboxylate, Glycolysis, Glactose metabolism

6177

Galactonate dehydratase

D,L-Malic acid

Carboxylate, TCA, malinate

2551, 2910

Malate:quinoneoxido reductase, Fumarate hydratase class

D-Ribose

Carbohydrate, Pentose and glucuronate interconversions

4585

ribokinase

1,2-Propanediol

Alcohol, Glycolysis, pyruvate metabolism

0496, 0497, 1546, 1547

Propanediol dehydratase

Alpha-Keto-Butyric Acid

Carboxylate, Glycine, serine and threonine metabolism

3183, 3532

threonine dehydratase, serine/threonine dehydratase family protein

Myo-Insitol

Carboxylate, Galactose Metabolism

2762, 3116, 3210

inositol-1-monophosphatase

Fumaric acid

Carboxylate, TCA

2985, 5240, 0417

Fumarate hydratase class I, anaerobic, fumarate reductase iron-sulfur subunit

L-Alanine

Aminoacid, TCA, oxaloacetate, Pyruvate

0688

aminotransferase

Pyruvic acid

Carboxylate, Pyruvate metabolism

2471,4323, 4711, 4712

pyruvate dehydrogenase

  1. Msm is observed to have higher growth in presence of the carbon sources mentioned in the table. The gene locus mentioned should be read as MSMEG_(number).