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Figure 1 | BMC Microbiology

Figure 1

From: Deep sequencing of HetR-bound DNA reveals novel HetR targets in Anabaenasp. strain PCC7120

Figure 1

Gene ontology categories for HetR ChIP peaks, and the consensus HetR binding site. A. GO Term gene categories for HetR target genes identified by ChIP. Significant enrichment in the GO Term categories “Heterocyst Differentiation” and “Transposon Related Functions” was seen in potential targets of HetR as identified by ChIP. These two categories were enriched at least 3-fold over their relative proportion in the genome as a whole. Each GO term is labeled with the percent of ChIP hits that fall within that category. B. Fold enrichment of HetR-ChIP target Go Terms over their representation in the Anabaena genome. For example, the category “Heterocyst differentiation” is represented over 12 times more often in the HetR-ChIP targets than would be expected from a random sampling of the genome. C. HetR consensus binding site in MEME format. Twenty ChIP peaks were queried with FiMO for the previously identified HetR binding site GGGTCTAgCCCagCA. 59 discovered sites were then aligned with the MEME suite to produce a consensus HetR binding site.

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