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Table 4 Differentially expressed miRNAs identified to be commonly presented in mouse lungs infected either with w81 or ma81 at 3 dpi

From: Differential microRNA expression following infection with a mouse-adapted, highly virulent avian H5N2 virus

miRNA w81‡ ma81‡
3dpi 3dpi
Fold change* P value§ Fold change P value
miR-100-5p† 2.6 0 2 0.007
miR-130a-5p† 3.2 0.01 2.2 0.03
miR-132-3p 3.3 0.01 3.6 0
miR-132-5p 2.6 0.015 2.7 0.049
miR-146b-5p 3.6 0.004 3.2 0.009
miR-146b-3p† 4.7 0.003 4.1 0.046
miR-147-3p† 22.8 0.012 25.2 0.04
miR-151-5p† 2.7 0.014 2.2 0.002
miR-154-3p 4.8 0.001 3.5 0.031
miR-155-3p† 3.5 0.016 6.2 0.018
miR-1943-3p 4.3 0.049 3.3 0.033
miR-212-3p 3.7 0 3.6 0.048
miR-214-3p 3 0.007 2.6 0.026
miR-223-3p† 3.4 0.009 8.9 0.013
miR-27a-5p 3.9 0.001 2.9 0.023
miR-29b-1-5p 2.1 0.037 2.2 0.021
miR-301a-3p† −2 0.048 −2 0.049
miR-361-3p 2.6 0.032 2.3 0.009
miR-495-3p† 2.9 0.01 2.3 0.004
miR-652-3p 2.8 0.011 2.7 0.032
  1. ‡ global cellular miRNA expression patterns in mouse lungs infected either with w81 or ma81 were compared with those of uninfected control mouse lungs. Differentially expressed miRNAs with a p < 0.05 and fold change>2 are described.
  2. *Sequence reads were normalized to determine the number of transcripts per million (TPM) using the following formula: Normalized expression = Actual miRNA count/Total count of clean reads*1000000. Then, fold changes of miRNAs were evaluated using the following formula: Fold change = log2 (treatment/control).
  3. §P-value was calculated from the normalized expression values as previously described [66].
  4. °Commonly upregulated at both 1 and 3 dpi.