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Table 3 Differentially expressed miRNAs identified to be commonly presented in mouse lungs infected either with w81 or ma81 at 1 dpi

From: Differential microRNA expression following infection with a mouse-adapted, highly virulent avian H5N2 virus

miRNA w81‡ ma81‡
1dpi 1dpi
Fold change* P value§ Fold change P value
let-7e-3p 2.6 0.008 2.5 0.048
miR-100-5p† 2.1 0.005 2 0.035
miR-130a-5p† 3.4 0.036 4.5 0.001
miR-146b-3p† 3.1 0.014 3.4 0.011
miR-147-3p† 2.7 0.013 7.8 0.045
miR-151-5p† 4.5 0.013 7.3 0.027
miR-155-3p† 2.3 0.015 6.2 0.024
miR-1843-3p 3.6 0.022 2.5 0.046
miR-190a-5p −5 0.033 −3.1 0.045
miR-2145 2.5 0.017 3.5 0.024
miR-219-5p −3.5 0.005 −2 0.039
miR-223-3p† 3.5 0.037 7.1 0.005
miR-299a-5p 2.3 0.004 2.1 0.018
miR-29b-3p −3.6 0.012 −2.7 0.047
miR-301a-3p† −6.9 0.019 −2.8 0.042
miR-30c-5p 2.5 0.038 2.6 0.035
miR-30e-5p −4.3 0 −2.7 0.022
miR-328-3p 4.1 0.011 3.7 0.034
miR-33-5p −6.5 0.024 −4.2 0.042
miR-3475-3p 2.8 0.019 2.3 0.011
miR-434-3p 2.3 0 3 0
miR-449a-5p −3.2 0.016 −2.5 0.046
miR-495-3p† 2 0.042 2.4 0.039
miR-503-5p −2.6 0.007 −2.6 0.029
miR-671-5p −2.6 0.038 −3.5 0.017
miR-700-5p 2 0.003 2.6 0.026
miR-99b-5p 3.1 0.007 3.1 0.032
  1. ‡ global cellular miRNA expression patterns in mouse lungs infected either with w81 or ma81 were compared with those of uninfected control mouse lungs. Differentially expressed miRNAs with a p < 0.05 and fold change>2 are described.
  2. *Sequence reads were normalized to determine the number of transcripts per million (TPM) using the following formula: Normalized expression = Actual miRNA count/Total count of clean reads*1000000. Then, fold changes of miRNAs were evaluated using the following formula: Fold change = log2 (treatment/control).
  3. §P-value was calculated from the normalized expression values as previously described [66].
  4. °Commonly upregulated at both 1 and 3 dpi.