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Table 2 Differentially expressed miRNAs identified to be commonly presented in ma81-infected mouse lungs at both 1 dpi and 3 dpi

From: Differential microRNA expression following infection with a mouse-adapted, highly virulent avian H5N2 virus

miRNA ma81‡
1dpi 3dpi
Fold change* P value§ Fold change P value
miR-100-5p† 2 0.035 2 0.007
miR-130a-5p† 4.5 0.001 2.2 0.03
miR-139-5p 4 0.031 3.8 0.003
miR-146b-3p† 3.4 0.011 4.1 0.046
miR-147-3p† 7.8 0.045 25.2 0.04
miR-151-5p† 7.3 0.027 2.2 0.002
miR-155-3p† 6.2 0.024 6.2 0.018
miR-223-3p† 7.1 0.005 8.9 0.013
miR-27a-5p 2.2 0.035 2.9 0.023
miR-29b-1-5p 2.7 0.043 2.2 0.021
miR-301a-3p† −2.8 0.042 −2 0.049
miR-449a-5p −2.5 0.046 −2.7 0.016
miR-495-3p† 2.4 0.039 2.3 0.004
miR-877-3p 3.1 0.04 4.4 0.04
  1. ‡ global cellular miRNA expression patterns in mouse lungs infected with ma81 were compared with those of uninfected control mouse lungs. Differentially expressed miRNAs with a p < 0.05 and fold change>2 are described.
  2. *Sequence reads were normalized to determine the number of transcripts per million (TPM) using the following formula: Normalized expression = Actual miRNA count/Total count of clean reads*1000000. Then, fold changes of miRNAs were evaluated using the following formula: Fold change = log2 (treatment/control).
  3. §P-value was calculated from the normalized expression values as previously described [66].
  4. †Significantly upregulated in both lungs infected with either wild type w81 or the mouse-adapted ma81 strain at all time points.