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Table 3 Structure of most effective inhibitors of SrtB ΔN26

From: Clostridium difficilehas a single sortase, SrtB, that can be inhibited by small-molecule inhibitors

Compound Structure IC50
LSHTM-0040   63.1 ± 8.8 μM
LSHTM-0050   60.1 ± 4.7 μM
LSHTM-0052   44.1 ± 6.9 μM