The PM has increased expression of genes in the hisidine biosynthesis pathway compared to the WT in standard media. Genes colored geen have greater than 2-fold higher expression and genes colored red have a greater than 2-fold lower expression in the PM than the WT in standard media. The extent of gene expression change and expression levels in other comparisons are given in Table 4. PRPP, 5-phosphoribosyl 1-pyrophosphate. ACR, aminoimidazole carboxamide ribonucleotide.