Table 2 List of 51 genes that are expressed 3-fold and lower in the wild-type versus Δ bsaN mutant strains (p < 0.01)
From: Characterization and analysis of the Burkholderia pseudomallei BsaN virulence regulon
Gene locus ID | Gene | Protein description | Fold repression |
|---|---|---|---|
T3SS3 apparatus | Â | ||
BPSS1545 | bsaO |  | −3.3 |
BPSS1547 | bsaM |  | −5.6 |
BPSS1548 | bsaL |  | −5.0 |
BPSS1549 | bsaK |  | −4.7 |
BPSS1550 | bsaJ |  | −3.9 |
BPSS1551 | orgA |  | −3.0 |
Flagella-dependent motility | Â | ||
BPSL0281 | flgL | Flagellar hook-associated protein | −3.3 |
BPSL3319 | fliC | Flagellin | −3.7 |
BPSL3320 | fliD | Flagellin | −3.0 |
BPSL3321 |  | Unknown | −3.1 |
Polyketide biosynthesis | Â | ||
BPSS0130 |  | Non-ribosomal peptide synthase | −3.1 |
BPSS0303-BPSS0311 |  | PKS biosynthesis locus | −3.0 - (−6.1) |
BPSS0328 |  | Malate/L-lactate dehydrogenase | −7.8 |
BPSS0329 |  | Fatty aldehyde dehydrogenase | −9.6 |
BPSS0330 |  | Amino acid transporter | −19.7 |
BPSS0331 |  | Dihydrodipicolinate synthase | −19.0 |
BPSS0332 |  | Hydroxyproline-2-epimerase | −21.7 |
BPSS0333 |  | Deaminating oxidase subunit | −18.8 |
BPSS0334 |  | Deaminating oxidase subunit | −24.7 |
BPSS0335 |  | Deaminating oxidase subunit | −20.1 |
BPSS0337 |  |  | −3.0 |
BPSS0338 |  | Transposase | −12.0 |
BPSS0339 |  | 4-Hydroxyphenylpyruvate | −8.2 |
Lipid metabolism | |||
BPSS2037 |  | Inner membrane fatty acid desaturase | −3.0 |
BPSS2038 |  | Acyl carrier protein | −3.4 |
BPSS2039 |  | Cyclopropane-fatty-acyl-phospholipid synthase | −3.6 |
BPSS2040 |  | Inner membrane fatty acid desaturase | −3.2 |
Energy metabolism | Â | ||
BPSL1744 | arcB | Ornithine carbamoyltransferase | −3.4 |
BPSL1745 | arcC | Carbamate kinase | −3.2 |
BPSL2404 |  | Periplasmic ligand binding protein | −7.3 |
BPSL2405 |  | FAD-dependent deaminase | −5.4 |
BPSS1885 |  | Aromatic hydrocarbons catabolism-related reductase | −3.1 |
BPSS1886 |  | Aromatic hydrocarbons catabolism-related dioxygenase | −4.2 |
BPSS1887 |  | Aromatic oxygenase | −3.1 |
BPSS1888 |  | Aromatic oxygenase | −3.0 |
BPSL2380 | cyoC | Cytochrome bo oxidase subunit | −3.4 |
BPSL2381 | cyoD | Cytochrome bo oxidase subunit | −3.0 |
Regulatory | Â | ||
BPSS0336 |  | AraC-type regulator, adjacent to polyketide genes | −8.1 |
Adaptation | Â | ||
BPSL3369 | acoD | Glycine betaine aldehyde dehydrogenase | −4.0 |