Complete nucleotide sequence of pRS218, a large virulence plasmid, that augments pathogenic potential of meningitis-associated Escherichia coli strain RS218

Table 1 Virulence and fitness-associated genes located on the genetic load region of pRS218

Gene name	Virulence/fitness-associated traits	Function	Reference
pRS218_010	Putative Na-translocating NADH dehydrogenase	Na⁺efflux (NrqC subunit)	[19]
pRS218_013	High affinity Fe²⁺permease	Iron acquisition	[13]
pRS218_014	High affinity Fe²⁺periplasmic component	Iron acquisition	[13]
pRS218_015	High affinity Fe²⁺ protein, membrane component	Iron acquisition	[13]
pRS218_016	High affinity Fe²⁺ binding protein, permease	Iron acquisition	[13]
pRS218_017	Putative ABC transport sys, permease	Type I secretion	[13]
pRS218_018	Putative ABC transport system, ATP-binding	Type I secretion	[13]
pRS218_019	TonB-dependent heme/hemoglobin receptor	Iron acquisition	[13]
pRS218_039	SenB	Enterotoxin in EIEC/Shigella	[26]
pRS218_001	Putative GTP binding protein, YihA	Cell signaling and membrane ruffling	[20]
pRS218_190	Hemolysin expression modulating protein	Thermo-osmotic regulation of hly	[13]
pRS218_007	Suppressor for copper sensitivity ScsC/ScsD	Copper tolerance	[25]
pRS218_022	Glucose-1-phosphatase	Virulence regulator	[21]
pRS218_116	Lytic transglycosylases	Cell division	[22]

ISSN: 1471-2180