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Table 2 Checkerboard assay* using Candida albicans strain

From: Synthetic organotelluride compounds induce the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisiae

 

Compound

Fluconazole

  

Compounds

MIC (μg/mL)

MIC combined (μg/mL)

FIC*

MIC (μg/mL)

MIC combined (μg/mL)

FICa

FICIb

Outcome

1

68.4

4.3

0.063

256

4

0.016

0.079

Synergy

2

70.0

4.4

0.063

256

4

0.016

0.079

Synergy

3

74.4

2.3

0.030

256

4

0.016

0.046

Synergy

5

74.9

2.3

0.031

256

4

0.016

0.047

Synergy

  1. *This assay was done with organotellurides and fluconazole isolated or combined.
  2. MICs were determined by a microdilution technique based on 80% reduction of growth. aFIC = fractional inhibitory concentration; bFICI = fractional inhibitory concentration index.
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BMC Microbiology

ISSN: 1471-2180

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