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Table 2 Checkerboard assay* using Candida albicans strain

From: Synthetic organotelluride compounds induce the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisiae

  Compound Fluconazole   
Compounds MIC (μg/mL) MIC combined (μg/mL) FIC* MIC (μg/mL) MIC combined (μg/mL) FICa FICIb Outcome
1 68.4 4.3 0.063 256 4 0.016 0.079 Synergy
2 70.0 4.4 0.063 256 4 0.016 0.079 Synergy
3 74.4 2.3 0.030 256 4 0.016 0.046 Synergy
5 74.9 2.3 0.031 256 4 0.016 0.047 Synergy
  1. *This assay was done with organotellurides and fluconazole isolated or combined.
  2. MICs were determined by a microdilution technique based on 80% reduction of growth. aFIC = fractional inhibitory concentration; bFICI = fractional inhibitory concentration index.