Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus

Seidl, Kati; Müller, Susanne; François, Patrice; Kriebitzsch, Carsten; Schrenzel, Jacques; Engelmann, Susanne; Bischoff, Markus; Berger-Bächi, Brigitte

doi:10.1186/1471-2180-9-95

BMC Microbiology

Table 4 CcpA-dependent genes coding for transport/binding proteins and lipoproteins regulated by glucose

From: Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus

ID			Product^a	wt	mut
N315	Newman	common		+/-^b	+/-^b
Down-regulated by glucose
SA0100	NWMN_0049		similar to Na+ P_i-cotransporter	0.2	1.7
*SA0186	NWNM_0136		sucrose-specific PTS tranporter IIBC component protein	0.4	1.2
*SA0302	NWNM_0255		probable pyrimidine nucleoside transport protein	0.4	1.8
SA1848	NWNM_1950	nrgA	probable ammonium transporter	0.4	0.8
SA2226	NWNM_2337		similar to D-serine/D-alanine/glycine transporter	0.2	0.9
SA2227	NWNM_2337		amino acid ABC transporter homologue	0.1	0.9
Up-regulated by glucose
SA0166	NWNM_0116		similar to nitrate transporter	2.8	1.1
SA0167	NWNM_0117		similar to membrane lipoprotein SrpL	2.8	1.6
SA0168	NWNM_0118		similar to probable permease of ABC transporter	2.3	1.1
SA0214	NWMN_0158	uhpT	hexose phosphate transport protein	2.1	1.1
SA0335	NWMN_0340		twin-arginine translocation protein TatA	2.2	1.4
SA0374	NWNM_0379	pbuX	xanthine permease	7.2	1.1
*SA0655	NWNM_0669	fruA	fructose specific permease	2.4	1.3
SA0769	NWNM_0780		D-methionine transport system ATP-binding protein	2.4	0.8
SA0770	NWNM_0781		D-methionine transport system permease	2.4	1.0
SA1270	NWNM_1347		similar to amino acid permease	2.0	1.1
SA2053	NWNM_2158		glucose uptake protein homologue	2.5	1.2
SA2234	NWMN_2344	opuCD	probable glycine betaine/carnitine/choline ABC transporter (membrane part) OpuCD	1.6	1.2
SA2235	NWMN_2345	opuCC	glycine betaine/carnitine/choline ABC transporter (osmoprotection) OpuCC	1.9	1.2
SA2236	NWMN_2346	opuCB	probable glycine betaine/carnitine/choline ABC transporter (membrane part) OpuCB	1.9	1.1
*SA2237	NWMN_2347	opuCA	glycine betaine/carnitine/choline ABC transporter (ATP-binding) OpuCA	2.6	1.0
SA2239	NWNM_2349		similar to amino acid transporter	2.2	1.1
SA2443	NWMN_2549		similar to accessory secretory protein Asp3	2.0	1.2
SA2444	NWMN_2550		similar to accessory secretory protein Asp2	2.3	1.3
Partially controlled by CcpA
SA0432	NWMN_0438	treP	PTS system, trehalose-specific IIBC component	0.5	0.2
SA1218	NWNM_1297	pstB	phosphate ABC transporter, ATP-binding protein (PstB)	0.5	2.6
SA1219	NWNM_1298		similar to phosphate ABC transporter	0.4	2.7
SA1220	NWNM_1299		similar to phosphate ABC transporter	0.3	3.7
SA1960	NWNM_2057	mtlF	PTS system, mannitol specific IIBC component	6.4	0.2
*SA2293	NWNM_2401	gntP	gluconate permease	0.7	2.5
SA2434	NWNM_2540		PTS system, fructose-specific IIABC component	1.2	0.4

^a Cellular main roles are in accordance with the N315 annotation of the DOGAN website [26] and/or the KEGG website [27].
^bComparison of gene expression with (+) and without (-) glucose, genes with a +/- glucose ratio of ≤ 0.5 or ≥2 in the wild-type were considered to be regulated
*Genes containing putative cre-sites

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ISSN: 1471-2180

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