Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus

BMC Microbiology

Table 3 Glucose-dependent genes regulated by CcpA and additional factors¹

ID			Product^a	wt	mut
N315	Newman	common		+/-^b	+/-^b
SA0432	NWMN_0438	treP	PTS system, trehalose-specific IIBC component	0.5	0.2
SA0433	NWNM_0439	treC	alpha-phosphotrehalose	0.7	0.3
SA0434	NWNM_0440	treR	trehalose operon repressor	0.7	0.3
SA1218	NWNM_1297	pstB	phosphate ABC transporter, ATP-binding protein (PstB)	0.5	2.6
SA1219	NWNM_1298		similar to phosphate ABC transporter	0.4	2.7
SA1220	NWNM_1299		similar to phosphate ABC transporter	0.3	3.7
SA1221	NWNM_1300	pstS	thioredoxine reductase	0.1	3.6
SA1586	NWNM_1659	ribH	6,7-dimethyl-8-ribityllumazine synthase	0.6	2.2
SA1587	NWNM_1660	ribA	riboflavin biosynthesis protein	0.6	1.8
SA1588	NWNM_1661	ribB	riboflavin synthase alpha chain	0.7	2.0
SA1589	NWNM_1662	ribD	riboflavin specific deaminase	0.7	2.0
SA1960	NWNM_2057	mtlF	PTS system, mannitol specific IIBC component	6.4	0.2
SA1961	NWNM_2058		similar to transcription antiterminator BglG family	0.9	0.4
SA2007	NWNM_2110	alsD	alpha-acetolactate decarboxylase	9.1	2.7
SA2008	NWNM_2111	alsS	alpha-acetolactate synthase	9.1	3.1
SA2293	NWNM_2401	gntP	gluconate permease	0.7	2.5
SA2294	NWNM_2402	gntK	gluconate kinase	1.6	3.7
*SA2295	NWNM_2403	gntR	gluconate operon transcriptional repressor	1.5	3.2
SA2321	NWMN_2432		hypothetical protein	0.1	2.5
SA2434	NWNM_2540		PTS system, fructose-specific IIABC component	1.2	0.4
SA2435	NWNM_2541	pmi	mannose-6-phosphate isomerase	1.2	0.4

¹Genes with parallel glucose-mediated regulation in wild-type and mutant but with different ratios, genes with divergent glucose-mediated regulation in wild-type and mutant, and genes with glucose-mediated regulation in the mutant but not in the wild-type
^a Cellular main roles are in accordance with the N315 annotation of the DOGAN website [26]and/or the KEGG website [27].
^b Comparison of gene expression with (+) and without (-) glucose, genes with a +/- ratio of ≤ 0.5 or ≥2 in the wild-type and the mutant were considered to be regulated)
* Genes containing putative cre-sites

ISSN: 1471-2180