Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus

BMC Microbiology

Table 2 Genes/operons with CcpA-independent regulation by glucose

ID			Product^a	wt	mut
N315	Newman	common		+/-^b	+/-^b
Down-regulated by glucose
SA0256	NWMN_0200	bglA	6-phospho-beta-glucosidase	0.5	0.5
SA0318	NWMN_0322		ascorbate-specific PTS system enzyme IIC	0.1	0.3
SA0319	NWMN_0323		similar to PTS system component	0.2	0.2
SA0320	NWMN_0324		similar to PTS transport system IIA component	0.2	0.2
SA0321	NWMN_0325		similar to PTS multidomain regulator	0.3	0.2
SA1991	NWMN_2093	lacG	6-phospho-beta-galactosidase	0.5	0.5
SA1992	NWMN_2094	lacE	PTS system, lactose-specific IIBC component	0.5	0.4
SA1993	NWMN_2095	lacF	PTS system, lactose-specific IIA component	0.4	0.4
SA1994	NWMN_2096	lacD	tagatose-1,6-diphosphate aldolase	0.5	0.4
SA1995	NWMN_2097	lacC	tagatose-6-phosphate kinase	0.6^§	0.6^§
SA1996	NWMN_2098	lacB	galactose-6-phosphate isomerase LacB subunit	0.5	0.4
SA1997	NWMN_2099	lacA	galactose-6-phosphate isomerase LacA subunit	0.6^§	0.5

^a Cellular main roles are in accordance with the N315 annotation of the DOGAN website [26] and/or the KEGG website [27].
^b Comparison of gene expression with (+) and without (-) glucose, genes with a +/- glucose ratio of ≤ 0.5 or ≥2 in the wild-type were considered to be regulated
^§ Genes with regulation above threshold, which were included in the list because they were part of a putative operon.

ISSN: 1471-2180