Histological analyses of female Calomys callosus infected i.p. with Paracoccidioides brasiliensis after bilateral ovariectomy. The tissue sections stained with haematoxylin-eosin were examined at a magnification of 200 X. In A and B – liver and spleen of animals 15 days post infection, C and D – liver and spleen 45 days post infection; E – liver 75 days post infection. Dead fungi cells are pointed with arrowheads. Giant cells are pointed with arrows.