Table 3 Antifungal activity of 20-piperidin-2-yl-5α-pregnan-3β,20-diol (AZA) and 24 (R,S),25-epiminolanosterol (EIL), Δ²⁴⁽²⁵⁾-sterol methyl transferase inhibitors, against 65 clinical isolates of Candida spp. by the CLSI reference broth microdilution method.

AZA

All species (65)

≤ 0.03 – > 16

0.5

2

Candida albicans (21)

0.06 – > 16

0.5

8

Candida parapsilosis (19)

0.06 – > 16

0.12

0.5

Candida tropicalis (14)

0.06 – > 16

0.62

8

Candida glabrata (2)

0.12 – > 16

1

2

Candida krusei (1)

16 – > 16

16

> 16

Candida lusitaneae (1)

0.06 – 0.5

0.06

0.5

Candida guilliermondii (3)

≤ 0.03 – 0.5

0.06

0.25

Candida zeylanoides (1)

≤ 0.03

≤ 0.03

≤ 0.03

Candida rugosa (1)

0.25 – 1

0.25

1

Candida dubliniensis (1)

0.5 – 2

0.5

2

Candida lipolytica (1)

> 16

> 16

> 16

EIL

All species (65)

≤ 0.03 – > 16

2

2

Candida albicans (21)

0.5 – 8

2

2

Candida parapsilosis (19)

0.5 – 8

1

2

Candida tropicalis (14)

1 – 8

1

2

Candida glabrata (2)

0.5 – 4

1

2

Candida krusei (1)

8

8

8

Candida lusitaneae (1)

0.5 – 2

0.5

2

Candida guilliermondii (3)

1 – 4

1

4

Candida zeylanoides (1)

1 – 2

1

2

Candida rugosa (1)

1 – 2

1

2

Candida dubliniensis (1)

2 – 8

2

8

Candida lipolytica (1)

≤ 0.03

≤ 0.03

≤ 0.03