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Table 1 Susceptibility of ATCC strains to Δ24(25) sterol methyl transferase inhibitors, 20-piperidin-2-yl-5α-pregnan-3β, 20-diol (AZA) and 24 (R,S), 25-epiminolanosterol (EIL), and standard antifungals (FLC, ITC, and AMB) by the broth microdilution method.

From: Growth inhibition and ultrastructural alterations induced by Δ24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms

Strains

AZA

EIL

FLC

ITC

AMB

 

MIC50

MIC90

MIC50

MIC90

MIC50

MIC90

MIC50

MIC90

MIC50

MIC90

C. albicans ATCC 10231

> 16

> 16

1

> 16

1

> 128T

0.5

> 16T

0.12

0.25

C. parapsilosis ATCC 22019

0.25

4

2

4

2

4

0.03

0.06

0.03

0.06

C. tropicalis ATCC 13803

0.25

4

1

2

0.25

2

< 0.03

0.03

0.007

0.25

C. krusei ATCC 6258

0.05

1

> 16

> 16

32

64R

0.12

0.25

0.25

0.25

C. glabrata ATCC 2001

1

2

> 16

> 16

4

> 128T

0.12

4T

0.03

0.12

  1. TTrailing Effect, RResistant
  2. The values are expressed in μg.ml-1.