Figure 6

Changes in gross and histopathology caused by C. jejuni strains during serial passage (experiment 2). Panels A-E, gross pathology; panels F-H, histopathology. In panels F-H, boxes enclose the central 50% of the scores; whiskers indicate the maximum and minimum scores; diamonds indicate the median score. All mice in all passages experienced a dietary shift from an ~12% fat diet to an ~6% fat diet 3 to 5 days prior to inoculation with C. jejuni. Passages 1, 2, and 3 had five infected mice each for each strain; passage four had 10 infected mice. Passage 1 had four sham inoculated control mice; passages 2 and 3 had five control mice each; passage four had 10 control mice. ICC, enlarged ileocecocolic lymph node; TW, thickened colon wall; BC, bloody contents in GI tract; TSB; sham inoculated control mice.