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Table 2 Summary of nucleotide changes and predicted outcomes of mutations in the agr locus.

From: Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus

Strain number Amount of TSST-1 produced (μg/ml) Changes in agrC region nucleotide sequence Predicted outcome tstpromoter sarA sigB
1 3.5 NC NC NC NC
2 14 T(321) insertion Frameshift→Truncated AgrC NC NC NC
3 5 T 281A phe→ile NC NC NC
7 2 NC NC NC NC
8 4 Δ495~504 Deletion of leu-lys-ile NC NC NC
9 2.8 NC NC NC NC
10 14 G651T glu→his NC NC NC
11 12 NC NC NC NC
16 1.3 NC NC NC NC
  1. Data are from DNA sequencing of agr loci, tst promoter region, sarA and sigB from 9 strains. All mutations were found in agrC. NC, no change.