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Table 2 Summary of nucleotide changes and predicted outcomes of mutations in the agr locus.

From: Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus

Strain number

Amount of TSST-1 produced (μg/ml)

Changes in agrC region nucleotide sequence

Predicted outcome

tstpromoter

sarA

sigB

1

3.5

NC

NC

NC

NC

2

14

T(321) insertion

Frameshift→Truncated AgrC

NC

NC

NC

3

5

T 281A

phe→ile

NC

NC

NC

7

2

NC

NC

NC

NC

8

4

Δ495~504

Deletion of leu-lys-ile

NC

NC

NC

9

2.8

NC

NC

NC

NC

10

14

G651T

glu→his

NC

NC

NC

11

12

NC

NC

NC

NC

16

1.3

NC

NC

NC

NC

  1. Data are from DNA sequencing of agr loci, tst promoter region, sarA and sigB from 9 strains. All mutations were found in agrC. NC, no change.