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Table 1 Mutations identified in 224 INH resistant M. tuberculosis isolates from South America

From: Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosisclinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America

  Specific mutation in each loci (number of isolates with mutation)
  katG only OxyR-ahpC only inhA (reg) only inhA (ORF) only KatG and inhA (reg) KatG and ahpC No mutation*
Brazil
(176)
S315T (121)
S315N (5)
S315I (3)
G258D*** (1)
C(-15)T (1)
I20I (1)**/***
C(-39)T (3)
C(-30)T (1)
G(-6)A (2)
G(-32)A (1)
C(-15)T (7) G(82)R*** (1) W300R***/C(-15)T (1)
S315T/C(-15)T (8)
S315N/I20I**/*** (1)
G299S/G(-9)A (1)
S315T/G(-48)A (1)
17
Peru
(34)
S315T (19)
S315N (2)
C(-10)T (1) C(-15)T (3) S(94) R*** (1) S315T/C(-15)T (1) S315N/C(-10)A*** (1)
S315T/C(-10)A*** (3)
S315T/C(-15)T (1)
2
Argentina
(14)
S315T (9) C(-15)T (1)
C(-10)T (1)
--- S(93)A*** (1) S315T/C(-15)T (1) --- 1
Total 224 N = 160 N = 12 N = 10 N = 3 N = 11 N = 8 N = 20
  1. *No mutation in studied loci.
  2. **Silent mutation in the codon 20 of the ahpC gene.
  3. ***Not reported in the literature.