Table 1 Mutations identified in 224 INH resistant M. tuberculosis isolates from South America
Specific mutation in each loci (number of isolates with mutation) | |||||||
|---|---|---|---|---|---|---|---|
katG only | OxyR-ahpC only | inhA (reg) only | inhA (ORF) only | KatG and inhA (reg) | KatG and ahpC | No mutation* | |
Brazil (176) | S315T (121) S315N (5) S315I (3) G258D*** (1) | C(-15)T (1) I20I (1)**/*** C(-39)T (3) C(-30)T (1) G(-6)A (2) G(-32)A (1) | C(-15)T (7) | G(82)R*** (1) | W300R***/C(-15)T (1) S315T/C(-15)T (8) | S315N/I20I**/*** (1) G299S/G(-9)A (1) S315T/G(-48)A (1) | 17 |
Peru (34) | S315T (19) S315N (2) | C(-10)T (1) | C(-15)T (3) | S(94) R*** (1) | S315T/C(-15)T (1) | S315N/C(-10)A*** (1) S315T/C(-10)A*** (3) S315T/C(-15)T (1) | 2 |
Argentina (14) | S315T (9) | C(-15)T (1) C(-10)T (1) | --- | S(93)A*** (1) | S315T/C(-15)T (1) | --- | 1 |
Total 224 | N = 160 | N = 12 | N = 10 | N = 3 | N = 11 | N = 8 | N = 20 |