Table 1 Fold changes in transcript levels of GBS genes.
From: Analysis of growth-phase regulated genes in Streptococcus agalactiaeby global transcript profiling
Gene | Fold change in S phase (S/ML ratio) | Putative function |
|---|---|---|
S phase related genes | ||
hrcA, grpE, dnaK (gbs0094–96), | +4 to +7.5 | Stress response |
clpE, and clpL (gbs0535 and gbs1376) | +4.5 and +7.5 | Chaperones |
gbs1202/1204, gbs1721, gbs1772 | + 30 to +64 | Putative stress response proteins from Gls24 and universal stress response families |
gbs2083–2085 | +350 to over +1000 | arginine/ornithine antiporter, carbamate kinase, ornithine carbamoyltransferase |
gbs2122–2126 | +55 to +150 | arginine deiminase ornithine carbamoyltransferase, arginine/ornithine antiporter carbamate kinase |
glpKDF (gbs0263–5) | +45 to +63 | putative operon responsible for glycerol uptake and utilization. |
Nutrient utilization and energy metabolism | ||
fba gbs0125 | +2.2 | fructose-bisphosphate aldolase |
plr gbs1811 | +3.1 | glyceraldehyde 3P-dehydrogenase |
pgk gbs1809 | +2.8 | phosphoglycerate kinase |
eno gbs0608 | +2.5 | enolase |
acoAB (gbs 0895–0896) | +4 | pyruvate dehydrogenase |
ldh gbs0947 | +2.8 | L-lactate dehydrogenase |
Regulators and signal transduction systems | ||
gbs 1671/2 | -2 | TCS CovR/S |
gbs1908/9 | +10/14 | TCS, homolog of GAS Spy1106/7 (SF370) |
gbs1934/5 | +5/+5 | TCS, homolog of Spy1061/2 (SF370) |
gbs2081/2 | -2.3/-1.7 | TCS, putative arginine utilization regulator |
gbs2086/7 | 2.5/2.6 | TCS, putative arginine utilization regulator |
gbs1834/5 | -7.5/-11.7 | TCS |
gbs1397/8 | -7/-5.8 | TCS |
gbs0597/8 | -5/-8.5 | TCS |
gbs0121/2 | -2/1 | TCS |
gbs0298/9 | -3/-1.8 | TCS |
gbs0309/10 | -3.3/-3 | TCS |
gbs0429/30 | -2.4/-1.6 | TCS |
gbs0963/4 | +1.7/+2 | TCS |
gbs1019/20 | -1.9/-1.9 | TCS |
gbs1947/8 | -3/-2.4 | TCS |
gbs1943/4 | -2.1/-2.7 | TCS |
gbs0680 | +3.1 | CcpA |
gbs0191 | +50 | putative transcriptional antiterminator of the BglG family |
gbs0469 | -34 | Regulator of unknown function |
relA (gbs1928) | -50 | GTP pyrophosphokinase |
codY (gbs1719;) | -8 | Global regulator |
luxS (gbs0294) | -3 | Quorum sensing |
mecA (gbs0135) | -20 | Global regulator of competence |
Virulence factors | ||
gbs1420 | +6.26 | choline-binding protein |
gbs1539 | +4.67 | cell wall anchored protein |
gbs1929 | +5.48 | putative nucleotidase |
gbs1143 | +2.61 | cell wall anchored protein |
gbs0451 | -2 | paralog of C5A peptidase precursor |
gbs1104 | -6.15 | cell wall anchored protein |
gbs1529 | -11 | putative fibronectin binding protein |
gbs0850 | -3 | putative fibronectin binding protein |
gbs1307 | -3 | laminin binding protein |
gbs1926 | -3 | putative laminin binding protein |
gbs1475/6 | -5.5 | sortases |
gbs0644–0654 | -1.6 to -2.8 | hemolysin |
gbs1061–1076 | -2.5 to -12.9 | pathogenicity island IX |
gbs1233–1247 | -3 to -12.4 | capsule synthesis |
cpsX gbs1250 | 4.4 | capsule synthesis regulator |
gbs1478/9, gbs1481, gbs1484/5, gbs1492–1494 | -3 to -12 | Putative group B antigen |
Cfa gbs2000 | +11.6 | CAMP factor |