Table 4 Summary of differentially regulated genes in the biofilm-batch comparison
From: A Candida albicans early stage biofilm detachment event in rich medium
Process GO Term | Genes on microarray dataset | Annotated Genes1 | P value | ||
|---|---|---|---|---|---|
| Â | 1h-biofilm | 3h-biofilm | Â | 1h-biofilm | 3h-biofilm |
Up regulated genes | 130 | 127 | Â | Â | Â |
Lipid metabolism | 21 | 18 | Â | Â | Â |
Ergosterol biosynthesis | 11 | 9 | 28 | 1.82 E-10 | 6.67 E-08 |
Fatty acid metabolism | 3 | 4 | 74 | 0.2 | 0.1 |
Other lipid metabolism | 7 | 5 | - | - | - |
Glycolysis | 13 | 7 | 16 | 5.74 E-18 | 1.75 E-07 |
Fermentation | 3 | 2 | 16 | 0.01 | 0.07 |
Amino acid biosynthesis | 11 | 5 | 205 | Â | Â |
Glutamate | 5 | 1 | 13 | 2.37 E-05 | 0.27 |
Leucine | 2 | 0 | 5 | 8.21 E-03 | - |
Other | 4 | 4 | - | - | - |
Transport | 12 | 4 | Â | Â | Â |
Glucose transport | 5 | 0 | 21 | 3 E-04 | - |
Oligopeptide transport | 3 | 0 | 11 | 3 E-03 | - |
Other | 4 | 4 | - | - | - |
Cell wall | 8 | 8 | 92 | 4.5 E-03 | 7.7 E-03 |
Protein refolding | 0 | 5 | 14 | - | 9 E-05 |
Down regulated genes | 71 | 95 | Â | Â | Â |
Translation (cytosolic ribosome) | 11 | 33 | 105 | Â | Â |
Large subunit | 8 | 18 | 50 | 9.08 E-05 | 8.1 E-15 |
Small subunit | 3 | 15 | 39 | 0.08 | 4.68 E-13 |
Tricarboxylic acid cycle | 6 | 2 | 20 | 1.75 E-05 | 0.11 |
Amino acid biosynthesis | 3 | 13 | Â | Â | Â |
Glutamate | 0 | 4 | 13 | - | 6.2 E-04 |
Leucine | 0 | 2 | 5 | Â | 9 E-03 |
Other | 3 | 7 | - | - | - |
ATP synthesis | 6 | 9 | 20 | 1.75 E-05 | 4.9 E-09 |
Respiratory chain | 8 | 11 | 26 | 5.36 E-07 | 2.02 E-10 |
Stress response | 4 | 5 | - | - | - |