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Table 4 Cellular Pathways involving up-regulated (p-value < 0.01) pig gene homologues in brain and lung tissues infected with wild type PRV.

From: Global transcriptional response of pig brain and lung to natural infection by Pseudorabies virus

Pathway Name

Library

Brain

Pig Unigene Matches over 60 base-pairs (gene homologues)

Brain

Pig Unigene

Matches

between 50-

59b base-

pairs (gene

homologues)

Lung Pig Unigene Matches over 60 base-pairs (gene homologues)

Lung

Pig Unigene Matches between 50-59b base-pairs (gene homologues)

Behavior

     

   Circadian rhythm

17

0

0

1

0

Cancers

     

   Colorectal cancer

73

2*

0

9

0

Cell Communication

     

   Adherens junction

72

2*

0

9

2

   Focal adhesion

187

4

1

11

4

   Gap junction

91

3*

0

5

0

   Tight junction

106

2

0

13

3

Cell Growth and Death

     

   Apoptosis

81

0

0

3

1

   Cell cycle

105

1

1*

12

4

Cell Motility

     

   Regulation of actin cytoskeleton

195

6*

0

12

2

Development

     

   Axon guidance

119

2

1

7

3

Endocrine System

     

   Adipocytokine signaling pathway

68

1

0

2

2

   GnRH signaling pathway

94

3*

2*

6

1

   Insulin signaling pathway

125

2

1

8

1

Folding, Sorting and Degradation

     

   Regulation of autophagy

24

0

0

2

0

   SNARE interactions in vesicular transport

28

0

1*

3

1

   Ubiquitin mediated proteolysis

41

0

1*

11*

1

Immune System

     

   Antigen processing and presentation

80

0

0

3

0

   B cell receptor signaling pathway

61

2*

0

6

1

   Complement and coagulation cascades

60

0

0

1

0

   Fc epsilon RI signaling pathway

73

2*

0

4

1

   Leukocyte transendothelial migration

111

1

0

6

3

   Natural killer cell mediated cytotoxicity

119

2

0

4

2

   T cell receptor signaling pathway

87

3*

0

5

3

   Toll-like receptor signaling pathway

87

1

0

6

0

Infectious Diseases

     

   Epithelial cell signaling in Helicobacter pylori infection

45

1

0

5

1

Metabolic Disorders

     

   Type I diabetes mellitus

42

1

1*

2

0

Nervous System

     

   Long-term depression

74

2*

0

5

0

   Long-term potentiation

65

2*

2*

5

3

Neurodegenerative disorders

     

   Neurodegenerative disorders

33

2*

1*

0

1

   Alzheimer's disease

18

0

0

2

0

   Amyotrophic lateral sclerosis (ALS)

17

3*

0

0

2*

   Dentatorubropallidoluysian atrophy (DRPLA)

12

0

0

1

0

   Huntington's disease

26

2*

1*

4

0

   Parkinson's disease

15

1*

0

0

0

   Prion disease

10

1*

0

3*

0

Sensory System

     

   Olfactory transduction

30

0

2*

2

0

   Taste transduction

51

1

0

1

0

Signal Transduction

     

   Calcium signaling pathway

173

0

4*

3

3

   Hedgehog signaling pathway

54

0

0

3

0

   Jak-STAT signaling pathway

147

0

0

6

2

   MAPK signaling pathway

267

5

2

18

7

   mTOR signaling pathway

44

0

0

4

3*

   Notch signaling pathway

39

0

0

1

0

   Phosphatidylinositol signaling system

77

0

1*

0

0

   TGF-beta signaling pathway

70

1

1*

11

0

   VEGF signaling pathway

68

3

0

5

2

   Wnt signaling pathway

138

0

1

12

2

Signaling Molecules and Interaction

     

   Cell adhesion molecules (CAMs)

123

2

1

3

2

   Cytokine-cytokine receptor interaction

242

0

0

3

2

   ECM-receptor interaction

85

1

0

3

2

   Neuroactive ligand-receptor interaction

275

1

0

1

0

  1. * Cellular pathways with at least five times the expected number of genes (calculated from the library composition).
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BMC Microbiology

ISSN: 1471-2180

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