Figure 5
Comparison of the prediction of w Bm gene essentiality by MHS and GCS. The X-axis shows normalized MHS on a log scale, while the Y-axis shows GCS. Grey lines indicate empirically determined thresholds for confidence in prediction of essentiality and are set at 7.3 × 10-3 for the MHS and 29 for the GCS. Therefore, the upper right quadrant contains genes with high confidence by both metrics. The upper left quadrant contains genes identified only by GCS, while the bottom right quadrant contains genes identified only by MHS. The numbers adjacent to the quadrant lines indicate gene counts in each quadrant. Red dots indicate Wolbachia genes which have significant protein sequence similarity to the targets of approved drugs and are predicted to be druggable.