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Table 4 Analysis of mutations resulting in nitrofurantoin resistance

From: Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae

Point mutationsa Frameshift mutation
Nonsense   Missense   Insertions (single site) Deletions (single site)
CAA->TAA 7 Transitions   Single base 22 Single base 16  
CAG->TAG 11 C->T 5 Multiple bases 4 Multiple bases 9  
TCG->TAG 9 T->C 2      
GAG->TAG 5 A->G 0      
TGG->TGA 1 G->A 1      
   Transversions    Mutations in promoter region 3
   T->A 3      
   A->T 0      
   G->C 1      
   C->G 1      
   T->G 5      
   G->T 0      
   A->C 0      
   C->A 2      
Total: 33   20   26   25 3
  1. aOf the 53 point mutations examined, 27 were transitions and 26 were transversions.