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Table 1 Summary of transcriptional changes in B. cereus ATCC14579 upon 0.5 μg/ml AS-48 treatment

From: Response of Bacillus cereus ATCC 14579 to challenges with sublethal concentrations of enterocin AS-48

Locus tag Expression ratioa Significance (p-value)b Annotationc Featured
Upregulated
BC4206 8.7 < 10-14 PadR-like transcriptional regulator PR
BC4207 8.7 < 10 -14 Hypothetical protein TMS(4)
BC4027 4.7 < 10 -14 NADH dehydrogenase subunit N TMS(6)
BC2842 4.0 10 -12 Hypothetical protein SS; TMS(2)
BC5438 3.7 10 -12 Antiholin-like protein TMS(7)
BC1612 3.7 10 -13 Na+/H+ antiporter SS; TMS (11)
BC2300 3.0 10 -11 Oxalate/formate antiporter SS; TMS(11)
BC5439 2.7 10 -10 Murein hydrolase regulator SS; TMS(4)
BC4528 2.4 10-11 Ferrichrome-binding protein PPD
BC4028 2.4 10 -10 NADH dehydrogenase subunit N TMS(6)
BC4268 2.4 10 -8 Phosphate transport system permease protein TMS(6)
BC4269 2.3 10-9 Phosphate-binding protein SS
BC4362 2.2 10 -7 Ferrichrome transport system permease protein TMS(9)
BC0223 2.2 10 -9 Hypothetical protein SS; TMS(1)
BC4029 2.2 10-11 PadR-like transcriptional regulator PR
BC5100 2.1 10 -8 Hypothetical protein SS; TMS(1)
BC0383 2.1 10-10 Ferrichrome-binding protein SS, PPD
BC3540 2.1 10-9 BNR-repeat containing protein  
BC3541 2.1 10-7 Flavodoxin Flavodoxin
BC0227 2.0 10 -9 Hypothetical protein TMS(1)
Downregulated
BC0409 0.3 10-12 Carbamate kinase Kinase
BC0406 0.3 10-12 Arginine deiminase Aminidotransferase
BC0407 0.3 10-12 Ornithine carbamoyltransferase Carbamoyl-P binding domain; Asp/Orn binding domain
BC0408 0.3 10 -12 Arginine/ornithine antiporter Permease; TMS(1)
  1. a The ratio of gene expression is shown. Ratio: expression in AS-48 treated sample over that in untreated samples.
  2. b Bayesian p value
  3. c Putative function of protein as annotated in the B. cereus ATCC14579 genome sequence
  4. d Domains detected using SMART search http://smart.embl-heidelberg.de/ (Letunic et al., 2006 Nucl Acid Res 34: D257-D260). PR; PadR domain; SS, signal sequence; TMS(n), transmembrane segment (n is the number of such domain); PPD, periplasm domain.
  5. Proteins with TMS are highlighted in bold