TY - JOUR AU - Corrigan, Rebecca M. AU - Miajlovic, Helen AU - Foster, Timothy J. PY - 2009 DA - 2009/01/30 TI - Surface proteins that promote adherence of Staphylococcus aureusto human desquamated nasal epithelial cells JO - BMC Microbiology SP - 22 VL - 9 IS - 1 AB - The natural habitat of Staphylococcus aureus is the moist squamous epithelium in the anterior nares. About 20% of the human population carry S. aureus permanently in their noses and another 60% of individuals are intermittent carriers. The ability of S. aureus to colonize the nasal epithelium is in part due to expression of surface proteins clumping factor B (ClfB) and the iron-regulated surface determinant A (IsdA), which promote adhesion to desquamated epithelial cells present in the anterior part of the nasal vestibule. S. aureus strain Newman defective in IsdA and ClfB exhibited reduced but not completely defective adherence to squamous cells in indicating that other cell surface components might also contribute. SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-9-22 DO - 10.1186/1471-2180-9-22 ID - Corrigan2009 ER -