Figure 7

Normal developmental forms of C. pneumoniae are found within compound D7-exposed inclusions. At 48 hpi, infected HeLa cells incubated in MEM containing 10 μM of either compound D6 or D7 were observed by TEM. A, B: inclusions in D7-exposed cells are smaller and contain fewer bacteria, but all three developmental forms (EB, IB and RB) of C. pneumoniae are present. C, D: C. pneumoniae inclusions exposed to compound D6 are normal in size and contain the same normal developmental forms. Size bars are indicated in white (500 nm). Representative micrographs indicating RB (arrows) and EB (arrow heads) are shown.