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Table 3 Protein-synthesis and energy-metabolism genes expressed differentially* by the BALF-exposed malT mutant

From: malT knockout mutation invokes a stringent type gene-expression profile in Actinobacillus pleuropneumoniae in bronchoalveolar fluid

Type of the product encoded by the differentially expressed gene

Up-regulated genes

Down-regulated genes

Ribosomal proteins and their modifiers

rpmE

rplQ, rpsQ, rplI, rpmG

tRNA base modifiers

queA

alaS, truD, trmU,

Transcription and transcription-related factors

 

deaD, rnc, rph, nusA, nusB

Amino acid biosynthetic enzymes

trpD, dapA, argD, proC, leuC, ilvH, tyrR

aroA, aroB,

Periplasmic nitrate reductase (nap operon)

 

napB, napG, napF, napD, napH

Nitrite reductase (nrf operon)

 

nrfB, nrfC

Dimethyle sulfoxide reducatse (dms operon)

 

dmsA, dmsB

Hydrogenases

 

hyaA, hybB

Amino acid catabolism

 

sdaA, aspA

pyruvate formate-lyase 1-activating enzyme

 

PflA

Glycolysis and gluconeogenesis

gpmB, pepC

FruK

TCA cycle enzymes

sucD, lpdA

 

Non-glucose hexose-monosaccharide metabolism enzymes

mtlD

nagZ

Products of central intermediary metabolism

 

ureA, ppx

ATP synthase

 

atpC, atpB

Formate dehydrogenase

 

fdhE

Products involved in fermentation

dld, aldA

 

Regulatory proteins

narP, sixA, gntR, cysB, asnC, gcvA, rseA

arcA, iclR

Cofactors

folA, folP, pdxY, thiH

hemB, chuW, lipA, ispA, ddc, dxs, ispE, iscA

  1. * Differential expression of a gene in the malT mutant is relative to the level of expression of the gene in the wild-type organism (reference sample) as measured in microarray experiments. For complete gene names and the fold changes in gene expression see Additional file 1: Analyzed microarray data.