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Table 2 List of MTases with statistically significant association with geographic area of strain isolation.

From: Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration

MTase Expression* Absence of expression*
M. AseI Europe
OR = 2.33; 95%CI (1.00-5.46) a)
Africa
P-value = 0.03083 Std. Residual 2.13e)
OR = 0.27; 95%CI (0.10-0.75) b)
M. BstUI Asia
P-value = 0.00639 Std. Residual 2.81e)
OR = 1/0.12 = 8.33; 95%CI (1.37-50.00) c)
OR = 1/0.07 = 14.29; 95%CI (2.13-100.00) d)
Africa
OR = 0.07; 95%CI (0.01-0.47) d)
Europe
OR = 0.12; 95%CI (0.02-0.73) c)
M. DraI Asia
P-value < 0.00001 Std. Residual 5.36e)
OR = 1/0.07 = 14.29; 95%CI (2.63-100.00) c)
Africa
Europe
OR = 0.07; 95%CI (0.01-0.38) c)
M. FauI Asia
P-value = 0.00403 Std. Residual -2.04e)
 
M. FokI America
P-value = 0.00058 Std. Residual 2.77e)
Asia
P-value = 0.00058 Std. Residual 2.50e)
Africa
Europe
OR = 0.12; 95%CI (0.02-0.70) a)
M. Hpy188I America
P-value = 0.00177Std. Residual 2.05e)
OR = 1/0.17 = 5.88; 95%CI (1.89-20.00) d)
OR = 1/0.37 = 2.70; 95%CI (1.09-6.67) c)
Asia
Africa
OR = 0.35; 95%CI (0.14-0.87) b)
OR = 0.17; 95%CI (0.05-0.53) d)
Europe
OR = 0.37; 95%CI (0.15-0.92) c)
M. Hpy99I America
P-value = 0.02544 Std. Residual 2.29e)
OR = 1/0.16 = 6.25; 95%CI (1.79-20.00) d)
OR = 1/0.35 = 2.86; 95%CI (1.14-7.14) c)
Africa
OR = 0.35; 95%CI (0.12-0.99) b)
OR = 0.16; 95%CI (0.05-0.56) d)
Europe
OR = 0.35; 95%CI (0.14-0.88) c)
M. HpyCH4III America
P-value = 0.00015 Std. Residual -2.21e)
OR = 1/0.19 = 5.26; 95%CI (1.15-25.00) c)
Africa
P-value = 0.00015 Std. Residual -1.99e)
OR = 4.44; 95%CI (1.46-13.47) b)
OR = 1/0.23 = 4.35; 95%CI (1.47-12.50) c)
OR = 4.34; 95%CI (1.46-12.87) d)
OR = 16.98; 95%CI (2.33-123.98) d)
Asia
OR = 1/16.98 = 0.06; 95%CI (0.01-0.43) d)
Europe
OR = 0.41; 95%CI (0.20-0.88) a)
OR = 1/4.34 = 0.23; 95%CI (0.08-0.68) d)
OR = 0.23; 95%CI (0.08-0.68) c)
OR = 0.19; 95%CI (0.04-0.87) c)
M. MspI Africa
P-value = 0.03638e)
OR = 4.42; 95%CI (1.46-13.43) b)
OR = 1/0.22 = 4.55; 95%CI (1.49-14.29) c)
OR = 4.51; 95%CI (1.49-13.67) d)
Europe
OR = 0.45; 95%CI (0.22-0.94) a)
OR = 1/4.51 = 0.22; 95%CI (0.07-0.67) d)
OR = 0.22; 95%CI (0.07-0.67) c)
  1. * Statistical analysis information:
  2. a) Multiple logistic regression: dependent variable Europe or non-Europe;
  3. b) Multiple logistic regression: dependent variable Africa or non-Africa;
  4. c) Multinomial regression: reference category Europe;
  5. d) Multinomial regression: reference category Africa;
  6. e) Chi-square independence test (p-value and std. residual);
  7. Note: in multinomial regression Odds Ratio (OR) values are determined for the absence of expression. The introduction of the inverse value allows the indication of OR value for presence of expression of each MTase. A OR 95% confidence interval is presented.