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Table 2 List of MTases with statistically significant association with geographic area of strain isolation.

From: Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration

MTase

Expression*

Absence of expression*

M. AseI

Europe

OR = 2.33; 95%CI (1.00-5.46) a)

Africa

P-value = 0.03083 Std. Residual 2.13e)

OR = 0.27; 95%CI (0.10-0.75) b)

M. BstUI

Asia

P-value = 0.00639 Std. Residual 2.81e)

OR = 1/0.12 = 8.33; 95%CI (1.37-50.00) c)

OR = 1/0.07 = 14.29; 95%CI (2.13-100.00) d)

Africa

OR = 0.07; 95%CI (0.01-0.47) d)

Europe

OR = 0.12; 95%CI (0.02-0.73) c)

M. DraI

Asia

P-value < 0.00001 Std. Residual 5.36e)

OR = 1/0.07 = 14.29; 95%CI (2.63-100.00) c)

Africa

Europe

OR = 0.07; 95%CI (0.01-0.38) c)

M. FauI

Asia

P-value = 0.00403 Std. Residual -2.04e)

 

M. FokI

America

P-value = 0.00058 Std. Residual 2.77e)

Asia

P-value = 0.00058 Std. Residual 2.50e)

Africa

Europe

OR = 0.12; 95%CI (0.02-0.70) a)

M. Hpy188I

America

P-value = 0.00177Std. Residual 2.05e)

OR = 1/0.17 = 5.88; 95%CI (1.89-20.00) d)

OR = 1/0.37 = 2.70; 95%CI (1.09-6.67) c)

Asia

Africa

OR = 0.35; 95%CI (0.14-0.87) b)

OR = 0.17; 95%CI (0.05-0.53) d)

Europe

OR = 0.37; 95%CI (0.15-0.92) c)

M. Hpy99I

America

P-value = 0.02544 Std. Residual 2.29e)

OR = 1/0.16 = 6.25; 95%CI (1.79-20.00) d)

OR = 1/0.35 = 2.86; 95%CI (1.14-7.14) c)

Africa

OR = 0.35; 95%CI (0.12-0.99) b)

OR = 0.16; 95%CI (0.05-0.56) d)

Europe

OR = 0.35; 95%CI (0.14-0.88) c)

M. HpyCH4III

America

P-value = 0.00015 Std. Residual -2.21e)

OR = 1/0.19 = 5.26; 95%CI (1.15-25.00) c)

Africa

P-value = 0.00015 Std. Residual -1.99e)

OR = 4.44; 95%CI (1.46-13.47) b)

OR = 1/0.23 = 4.35; 95%CI (1.47-12.50) c)

OR = 4.34; 95%CI (1.46-12.87) d)

OR = 16.98; 95%CI (2.33-123.98) d)

Asia

OR = 1/16.98 = 0.06; 95%CI (0.01-0.43) d)

Europe

OR = 0.41; 95%CI (0.20-0.88) a)

OR = 1/4.34 = 0.23; 95%CI (0.08-0.68) d)

OR = 0.23; 95%CI (0.08-0.68) c)

OR = 0.19; 95%CI (0.04-0.87) c)

M. MspI

Africa

P-value = 0.03638e)

OR = 4.42; 95%CI (1.46-13.43) b)

OR = 1/0.22 = 4.55; 95%CI (1.49-14.29) c)

OR = 4.51; 95%CI (1.49-13.67) d)

Europe

OR = 0.45; 95%CI (0.22-0.94) a)

OR = 1/4.51 = 0.22; 95%CI (0.07-0.67) d)

OR = 0.22; 95%CI (0.07-0.67) c)

  1. * Statistical analysis information:
  2. a) Multiple logistic regression: dependent variable Europe or non-Europe;
  3. b) Multiple logistic regression: dependent variable Africa or non-Africa;
  4. c) Multinomial regression: reference category Europe;
  5. d) Multinomial regression: reference category Africa;
  6. e) Chi-square independence test (p-value and std. residual);
  7. Note: in multinomial regression Odds Ratio (OR) values are determined for the absence of expression. The introduction of the inverse value allows the indication of OR value for presence of expression of each MTase. A OR 95% confidence interval is presented.