Pherotypes are driving genetic differentiation within Streptococcus pneumoniae

BMC Microbiology

Table 3 Association between antibiotic resistance and pherotype.

Antibiotic	CSP-1		CSP-2		OR (95% CI)^a	FDR^b
	Resistant	Susceptible	Resistant	Susceptible
Penicillin^{c, d}	92	249	21	121	2.13 (1.24;3.78)	0.012
Erythromycin	32	309	16	126	0.82 (0.42;1.65)	0.611
Clindamycin	22	319	16	126	0.54 (0.26;1.15)	0.141
Tetracycline^d	18	323	20	122	0.31 (0.16;0.70)	0.010
Chloramphenicol^d	5	336	9	133	0.22 (0.05;0.75)	0.013
Co-trimoxazole^d	89	252	17	125	2.59 (1.45;4.86)	0.005
Cefuroxime^d	68	272	12	129	2.68 (1.38;5.64)	0.010

^a Odds ratio (OR) measures the strength of the association between a pherotype and resistance to a particular antibiotic. In each case, if OR is significantly > 1, CSP-1 is associated with resistance to that antibiotic and if OR is significantly < 1 this means that CSP-2 is associated with resistance to that particular antibiotic.
^b Correction for multiple testing performed by the false discovery rate method (FDR)
^c p < 0.05 after FDR correction.
^d Both penicillin intermediate and fully resistant isolates were considered resistant for this analysis.

ISSN: 1471-2180