Advertisement
Table 1 Modules and sub-modules found in the B. subtilis glucose-responding regulatory network.
| Module | Physiological function | Genes |
|---|---|---|
| M1 | Heat shock response | acoR(↓), alsS(↑), arfM, alsR, ydiH, cydC(↑), dnaK(↓), grpE(↓), lctP(↑), hrcA, resD, groEL(↓), groES(↓) |
| Carbon catabolism | glpK(↓), glpP, ahrC, rocR, iolR, araB(↓), araN(↓), acuB(↓), galK(↓), msmX(↓), pta(↓), bglH(↓), bglP(↓), yxiE(↓), licA(↓), licB(↓), licC(↓), licH(↓), treA(↓), treP(↓), ccpA, iolC(↓), iolF(↓), iolH(↓), iolI(↓), ccpB, xylR, xylA(↑), araR, treR, licR, licT, levD(↓), levE(↓), levR, sigL, rocA(↑), ydjK(↓), rbsA(↓), rbsB(↓), rbsC(↓), rbsD(↓), rbsK(↓), rbsR(↓) | |
| M2 | Endospore formation | citG(↓), codY, dppE(↓), hag(↑), abrB, sigH, spoVG(↓), yxnB(↓) |
| Sporulation | dltA(↑), dltB(↑), dltD(↑), dltE(↑), mcpB(↑), yjcP(↑), yvyC(↓), sigD | |
| MM1 | Sporulation | sigX, spo0A |
| M3 | Prespore formation | comA, yvrH, wprA(↓), degQ(↓), wapA(↑), sacA(↓), sacP(↓), degU, sacT, sacY, tenA, yveB(↓), sigG, gerKA(↓), ybxH(↓), sspD(↑), spoVAD(↓), spoVAC(↑), sspJ(↓), sspM(↑), adhB(↓), yraG(↓), yraE(↓), yraD(↓), yndE(↑), ylaJ(↓), sspN(↓) |
| Spore formation | ctsR, bofC(↓), csbX(↑), sigF, spoVT, sigB, clpP(↓), rsbW(↓), ydaE(↓), ydhK(↓), yjgB(↑), gcaD(↑), yycD(↓), ysnF(↓), ypuB(↑), yoxB(↓), yotK(↑), yqhQ(↓), spoIIQ(↑), yfhD(↓), yfhE(↓), yhcM(↓), yqzG(↓) | |
| MM2 | Glycerophospholipid metabolism | glpQ(↓), glpT(↓), phoP |
| M4 | Hexuronate metabolism | exuR, mmgA(↓), yjmC(↓) |
| M5 | Nitrogen metabolism | glnR, glnA(↑), glnP(↑), kipR, tnrA, ykoL(↓), ykzB(↑) |
| Spore coat formation | gerE, spoIIIC, spoIVCB, cotB(↓), cotC(↓), cotV(↓), cotW(↓), cotT(↓), cgeA(↓), cgeB(↓), cotZ(↓), sspG(↓), cgeC(↓), yurS(↓), yoaN(↑), yjcB(↓), spoVFA(↓), yisZ(↓), ykvP(↓), ykvQ(↓), ylbD(↓), ylbE(↓), cotS(↓), ywrJ(↓), ytxO(↓), ytcC(↓), ytaA(↓), yqfQ(↓), yodH(↓), yngK(↓), ymaG(↓), spsA(↓), spsI(↓), ycsF(↓), spoIIID, ylbO, yhcO(↓), yhcP(↓), ypqA(↓), ysnD(↓) | |
| M6 | SOS response | lexA, ybaK(↓), aprX(↓), yozM(↓), yozL(↑) |
| Prospore formation | spoIIIAC(↓), yqfZ(↓), sigE, usd(↓), mbl(↑), yheD(↓), yjcA(↓), yncD(↓), yngE(↓), yngG(↓), ywdL(↓) | |
| MM3 | Glycolysis | cggR, eno(↑), pgk(↑), pgm(↑) |
| MM4 | Nitrogen assimilation | fnr, narG(↓), narH(↑) |
| M7 | Competence | comK, comGB(↑), cspB(↓), yhjC(↓), yhcD(↑), ssb(↑), rpsF(↑), rpsR(↑) |
| MM5 | Peroxide stress | ahpC(↓), ahpF(↓), perR |
| MM6 | PTS-glucose system | glcT, ptsG(↑), ptsI(↑) |
| MM7 | Amine and polyamine degradation | bltD(↓), bltR, mta |
| MM8 | Extracytoplasmic | sigY, yxlC(↓), yxlE(↓) |
| MM9 | Aspartate catabolism | ansB(↓), ansR |
| MM10 | N/A | lmrA, yxaH(↓) |
| MM11 | N/A | fur, ydhU(↓) |
| MM12 | N/A | rok, yydH(↓) |
| MM13 | Sorbitol catabolism | gutB(↓), gutR |
| MM14 | Purine metabolism | purQ(↑), purr |
| MM15 | N/A | birA, ytbQ(↑) |
| MM16 | N/A | yufM, ywkB(↑) |
| MM17 | N/A | appC(↓), hpr |
| MM18 | Lactose catabolism | lacA(↓), lacR |
| M8 | Extracytoplasmic | sigW, yceC(↓), yceD(↑), yceF(↓), ydjH(↓) |
| M9 | Cysteine biosynthesis | cysK(↓), ytmI(↓), ytmJ(↓), ytmK(↑), ytmL(↓), ytnI(↓), ytnM(↓), yrzC, ytlI |
