Figure 1

Protective effect of A5/L phages on S. aureus infected mice pretreated with cyclophosphamide. A: spleen, B: liver, C: kidney. Mice were given CP (350 mg/kg b.w.). After four days A5/L phages (10⁶) were administered 30 minutes before infection of mice with 5 × 10⁶ of S. aureus. 24 h later the CFU were enumerated in the organs. The number of mice per group: n = 20. Statistics: A: CP^-P^-B⁺ vs CP⁺P^-B⁺ P = 0.0004; CP⁺P^-B⁺ vs CP⁺P⁺B⁺ P = 0.0169 (ANOVA of Kruskal-Wallis; P = 0.0000); B: CP^-P^-B⁺ vs CP⁺P^-B⁺ P = 0.0004; CP⁺P^-B⁺ vs CP⁺P⁺B⁺ P = 0.0009 (ANOVA of Kruskal-Wallis; P = 0.0000); C: CP^-P^-B⁺ vs CP⁺P^-B⁺ P = 0.0001; CP⁺P^-B⁺ vs CP⁺P⁺B⁺ P = 0.0370 (ANOVA of Kruskal-Wallis; P = 0.0000).