Skip to main content

Advertisement

Table 2 Cytokine elaboration from human monocyte-derived macrophages following exposure to M. genitalium G37a.

From: Intracellular Mycoplasma genitalium infection of human vaginal and cervical epithelial cells elicits distinct patterns of inflammatory cytokine secretion and provides a possible survival niche against macrophage-mediated killing

Human MDM
  Viable UV-Inactivated PBS
IL-1β 31 ± 6.1* 33 ± 1.4* 0.7 ± 0.04
IL-6 385 ± 13.8* 439 ± 4.0* 3.2 ± 0.1
IL-8 5784 ± 149* 5368 ± 564* 116 ± 7.8
G-CSF 63.1 ± 5.5* 72 ± 2.4* 6.2 ± 0.1
IFN-γ 270 ± 24* 339 ± 3.9* 9 ± 3.6
MCP-1 298 ± 9.3* 318 ± 8.3* 36 ± 3.9
MIP-1α 1056 ± 16* 1068 ± 4.0* 176 ± 10.9
MIP-1β 2514 ± 57* 2403 ± 19* 810 ± 47
RANTES 66 ± 1.5* 74 ± 9.9* 11.4 ± 0.4
TNF-α 7456 ± 334* 8616 ± 697* 20 ± 2.0
  1. aHuman MDM were inoculated with M. genitalium G37 (MOI 10) or an equal volume of the PBS vehicle as a control into triplicate wells. Culture supernatants were collected 6 h PI to quantify secreted cytokines as described in the Methods. Values are expressed as the mean ± SEM pg/mL supernatant. PBS values are presented to indicate basal cytokine elaboration. Data collected following exposure to M. genitalium strain M2300 were similar in pattern and magnitude. ND, not detected. *, p < 0.01 using ANOVA.