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Table 1 Cytokine elaboration from human genital epithelial cells following M. genitalium G37 exposurea.

From: Intracellular Mycoplasma genitalium infection of human vaginal and cervical epithelial cells elicits distinct patterns of inflammatory cytokine secretion and provides a possible survival niche against macrophage-mediated killing

  Vaginal (V19I, V12I, V11I) Ectocervical (3ECI) Endocervical (sA2EN)
  MOI 10 PBS MOI 10 PBS MOI 10 PBS
IL-6 127 ± 13.1* 69 ± 1.7 63.7 ± 1.8* 21.3 ± 2.4 348 ± 13* 196 ± 15
IL-8 1458 ± 117* 785 ± 11.3 3304 ± 300* 722 ± 98 5e7 ± 1347* 6e4 ± 367
G-CSF 261 ± 46 227 ± 37 548 ± 143 779 ± 122 155 ± 6.2* 93 ± 21
GM-CSF 24 ± 1.8* 8 ± 3.1 16 ± 2.6 10 ± 1.0 160 ± 9.4* 45 ± 12
MCP-1 5.8 ± 1.4 7 ± 2.1 11.4 ± 1.3 10 ± 3.1 7.2 ± 1.1* 0.46 ± 0.02
  1. aHuman vaginal (n = 3 donors), ectocervical or endocervical ECs were inoculated with M. genitalium G37 (MOI 10). An equal volume of the PBS vehicle was added and processed in parallel as a control. Culture supernatants were collected 48 h PI to quantify secreted cytokines. Values are expressed as the mean ± SEM pg/mL from triplicate wells. Cytokine elaboration pattern and magnitudes induced following exposure to strain M2300 were not significantly different than G37. PBS values are presented to indicate basal cytokine elaboration from each cell type. ND, not detected. *, p < 0.05 vs. PBS control using Student's t-test.