Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)

Table 1 Biological effects of six potential inhibitors of the VicK histidine kinase

Chemical inhibitor	MIC (μM)	MBC (μM)	CC₅₀ (μM) on Vero cell	IC₅₀ (μM) for VicK' protein
Compound 1	100	>200	213	542.25
Compound 2	50	200	321.33	562.41
Compound 3	100	>200	274.22	502.63
Compound 4	200	>200	360	>1000
Compound 5	100	>200	516.17	598.11
Compound 6	0.28	25	392	32.60
PNC	0.02	2.0	undone	undone

ISSN: 1471-2180