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Figure 7 | BMC Microbiology

Figure 7

From: Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)

Figure 7

Therapeutic efficacies of each lead compound against infection with S. pneumoniae ATCC7466 in mice. Figure shows the cumulative survival (survival probability) of the mouse infection models treated differently in the following 8 days (survival time more than 8 days was censored). Data were analyzed by using the survival analysis approach (Kaplan-Meier Method). Significant treatment effects were found among the groups (P < 0.01) by an overall comparison. Pairwise comparisons revealed that compounds 1–6 prolonged survival time in mouse infection models as compared to negative control (p < 0.01), and that compound 4 and 5 were almost as effective as positive control PNC (P > 0.1), but the other compounds were less effective than it (P < 0.05 or P < 0.1). *P < 0.01 indicates significant differences as compared to negative control; #P < 0.05 and $P < 0.1 indicate significant differences as compared to positive control.

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BMC Microbiology

ISSN: 1471-2180

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