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Table 1 Apoptotic markers included in the qPCR-Array shown in Fig. 1.

From: Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism

Genes Killed Pg MOI:100 4 h Killed Pg MOI:100 24 h Live Pg MOI:100 4 h Live Pg MOI:100 24 h
LTA 4.7 ± 3.4** 0.4 ± 0.1*** 1.1 ± 0.8* 3.8 ± 1.2**
TNF 0.4 ± 0.01 2.0 ± 0.01** 2.1 ± 0.2*** 1.6 ± 0.1***
NFKB1 0.5 ± 0.01 1.4 ± 0.03 0.9 ± 0.1* 1.5 ± 0.05*
TRADD 0.8 ± 0.01 1.5 ± 0.3** 0.9 ± 0.2 3.4 ± 0.1***
BID 0.7 ± 0.02 1.6 ± 0.1*** 0.9 ± 0.1* 3.1 ± 0.08***
CASP9 1.9 ± 0.7** 0.6 ± 0.2* 2.4 ± 1.1** 2.2 ± 0.2**
CASP3 1.2 ± 0.02* 1.0 ± 0.01 1.2 ± 0.1* 2.2 ± 0.4***
BAX 1.5 ± 0.5* 1.0 ± 0.08 1.2 ± 0.01 1.7 ± 0.8**
BCL2 0.9 ± 0.02** 0.7 ± 0.02** 0.9 ± 0.1** 1.2 ± 0.7*
FADD 1.2 ± 0.01 1.0 ± 0.01 1.2 ± 0.1* 1.3 ± 0.05**
RELA 0.9 ± 0.03** 1.2 ± 0.05** 1.1 ± 0.08* 1.5 ± 0.1***
ENDO-G 0.9 ± 0.01 1.0 ± 0.01 1.0 ± 0.1 1.3 ± 0.1**
CHUK 0.9 ± 0.06* 1.2 ± 0.08** 1.1 ± 0.1* 1.2 ± 0.3**
CASP8 0.9 ± 0.01** 1.0 ± 0.07 1.0 ± 0.1 1.1 ± 0.1**
FASLG 1.3 ± 0.02 1.3 ± 0.02** 1.5 ± 0.1** 0.9 ± 0.2**
DFFB 1.3 ± 0.03** 1.0 ± 0.1 1.2 ± 0.2* 0.8 ± 0.01
  1. HGECs were challenged with live or heat-killed P. gingivalis 33277 at MOI:100 for 4 and 24 hours. Negative control was unchallenged HGECs in media. The data shown represent log-fold differences in gene expression (means ± SD) between the respective sample and the negative control. A value of 1 indicates no change, less than one indicates down-regulation and greater than one, up-regulation (*P < 0.05 ** P < 0.01, *** P < 0.001)