Skip to main content

Table 1 Overview of the comparison of the broth dilution method as described by the CLSI [15] and the IMC method developed in this study.

From: Isothermal micro calorimetry – a new method for MIC determinations: results for 12 antibiotics and reference strains of E. coli and S. aureus

  MIC (CLSI) [mg l-1] MIC (IMC) [mg l-1] t delay [min] P max [μW]
E. coli     
Cefazoline 2 2 54 666
Cefoxitin 8 8 402 174
Ampicillin n. d.a n. d. 0 454
Piperacillin 4 4 445 237
Aztreonam n. d. n. d. 950 57
Amikacin n. d. n. d. 1145 o. t.b
Gentamycin 1 1 560 486
S. aureus     
Cefoxitin 4 4 412 80
Vancomycin 1 1 147 339
Chloramphenicol 16 16 630 o. t.
Erythromycin 0.5 0.5 638 27
Tetracycline 0.25 0.25 330 27
Ciprofloxacin 0.5 0.5 1097 17
(almost o. t.)
  1. t delay and P max show the values of the curves determined at one concentration below the MIC value.
  2. a n. d.: not determinable using the tested concentrations.
  3. b o. t.: Outside measuring time.