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Table 1 Overview of the comparison of the broth dilution method as described by the CLSI [15] and the IMC method developed in this study.

From: Isothermal micro calorimetry – a new method for MIC determinations: results for 12 antibiotics and reference strains of E. coli and S. aureus

 

MIC (CLSI) [mg l-1]

MIC (IMC) [mg l-1]

t delay [min]

P max [μW]

E. coli

    

Cefazoline

2

2

54

666

Cefoxitin

8

8

402

174

Ampicillin

n. d.a

n. d.

0

454

Piperacillin

4

4

445

237

Aztreonam

n. d.

n. d.

950

57

Amikacin

n. d.

n. d.

1145

o. t.b

Gentamycin

1

1

560

486

S. aureus

    

Cefoxitin

4

4

412

80

Vancomycin

1

1

147

339

Chloramphenicol

16

16

630

o. t.

Erythromycin

0.5

0.5

638

27

Tetracycline

0.25

0.25

330

27

Ciprofloxacin

0.5

0.5

1097

17

(almost o. t.)

  1. t delay and P max show the values of the curves determined at one concentration below the MIC value.
  2. a n. d.: not determinable using the tested concentrations.
  3. b o. t.: Outside measuring time.
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BMC Microbiology

ISSN: 1471-2180

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