Heatflow data (column A) and resultant cumulative heat curves (column B) for IMC determinations of the MICs of the respective cephalosporines for E. coli ATCC25922 incubated at 37°C. Culture medium was cation-adjusted Mueller-Hinton II broth. t1, t2: t
for 0 mg l-1 antibiotic; t3: t
for 4 mg l-1 cefoxitin. Blank is medium alone. Curves are the mean of three replicates.