TY - JOUR AU - Zaczek, Anna AU - Brzostek, Anna AU - Augustynowicz-Kopec, Ewa AU - Zwolska, Zofia AU - Dziadek, Jaroslaw PY - 2009 DA - 2009/01/15 TI - Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin JO - BMC Microbiology SP - 10 VL - 9 IS - 1 AB - Rifampin is a first line antituberculosis drug active against bacilli in logarithmic and stationary phase, which interferes with RNA synthesis by binding to bacterial RNA polymerase. Tubercle bacilli achieve resistance to rifampin by accumulation of mutations in a short-81 bp region of the rpoB gene. Among many mutations identified in the rpo B gene, few were verified by molecular genetic methods as responsible for resistance to rifampin (RMP). SN - 1471-2180 UR - https://doi.org/10.1186/1471-2180-9-10 DO - 10.1186/1471-2180-9-10 ID - Zaczek2009 ER -