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Table 2 Comparison of accuracy of various assays for detection of H. pylori infection

From: Prevalence of A2143G mutation of H. pylori-23S rRNA in Chinese subjects with and without clarithromycin use history

Assays Sensitivity Specificity Youden's index1
23S rRNA PCR2 83.4% (373/447) 75.5% (114/151) 0.59
13C-UBT3 94.9% (373/393) 70.8% (114/161) 0.66
ELISA4 95.2% (373/392) 63.7% (114/179) 0.59
  1. 1: defined as "sensitivity + specificity - 1";
  2. 2: both 13C-UBT and ELISA were positive or negative for comparison;
  3. 3: both PCR and ELISA were positive or negative for comparison;
  4. 4: both PCR and 13C-UBT were positive or negative for comparison.