Complete genome sequence of Treponema pallidum ssp. pallidumstrain SS14 determined with oligonucleotide arrays

Table 6 Distribution of SNPs in different gene function groups and their effects on protein sequences

Putative gene function	whole genome^a	%	affected ORFs^b	%	SNPs^c	%	aa changes^d	%
Hypothetical	316	30.4	52	38.2	199	64.2	148	67.0
Conserved hypothetical	177	17.0	21	15.4	34	11.0	22	10.0
Metabolic functions	167	16.1	19	14.1	23	7.4	19	8.6
Housekeeping genes	223	21.5	24	17.6	25	8.0	10	4.4
Other function	156	15.0	20	14.7	29	9.4	22	10.0
Total	1039	100	136	100	310	100	221	100

^anumber of genes (ORFs) in the complete genome of TPA Nichols strain [3]; ^bnumber of all genes with sequence changes in the genome of SS14 strain; ^cnumber of SNP changes identified within ORF groups in the genome, other sequence changes were not included; ^damino acid changes caused by SNPs, changes in length of the protein molecule are listed in Table 4.

ISSN: 1471-2180