Complete genome sequence of Treponema pallidum ssp. pallidumstrain SS14 determined with oligonucleotide arrays

Table 5 ORFs with the highest number of detected SNPs (+ indels)

ORF^a	SNPs	aa changes	Other changes	Result of mutation	Protein function
TP0117	10	6			Tpr protein C (TprC)
TP0136	49	38	4 deletions (9 nt)	3 aa missing	hypothetical protein^b
TP0326	12	9			outer membrane protein
TP0515	10	10			conserved hypothetical protein
TP0548	30	21	3 insertions (12 nt)	4 aa inserted	hypothetical protein
TP1031	31	23			Tpr protein L (TprL)

ORF – open reading frame; SNP – single nucleotide polymorphism; aa – amino acid; nt – nucleotide; ^aas described in [3]; ^bthis protein was described to be fibronectin and laminin protein [29].

ISSN: 1471-2180