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Table 4 Genes with mutations that significantly affect protein length

From: Complete genome sequence of Treponema pallidum ssp. pallidumstrain SS14 determined with oligonucleotide arrays

ORFa SNPs Other changes Result of mutation Protein function
TP0006 1 read-through stop codon longer protein (+262 aa), fusion with TP0007 Tp75 protein (possible surface protein)
TP0127 0 1 deletion (2 nt) frameshift (-103 aa) hypothetical protein
TP0132 0 1 insertion (1 nt) frameshift (-44 aa) hypothetical protein
TP0433–TP0434 1 insertion of tandem repeats fusion of 2 ORFs (604 aa) hypothetical proteins (resulting fusion – arp proteinc)
TP0468–TP0469 0 1 insertion (2 nt)
1 deletion (1 nt)
fusion of 2 ORFs (650 aa) conserved hypothetical proteins
TP0470 0 deletion of 7 tandem repeats (7 × 24 nt) shorter protein (-56 aa) conserved hypothetical protein
TP0486 0 1 deletion (1 nt)b frameshift (+9 aa) antigen, p83/100 (possible surface protein)
TP0598 1 4 insertion (4 nt)b frameshift (+81 aa) fusion with TP0597 hypothetical protein
TP0868 0 1 deletion (7 nt) frameshift (-168aa) flagellar filament 34.5 kDa core protein (FlaB1)
TP0924 1 nonsense mutation shorter protein (-250 aa) Tex protein
TP1030 7 1 insertion (1 nt) frameshift (-46 aa) hypothetical protein
  1. ORF – open reading frame; SNP – single nucleotide polymorphism; aa – amino acid; aas described in [3]; bsame sequence change detected in Nichols Houston strain genomic DNA; c same sequence change described in [19].