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Table 4 Genes with mutations that significantly affect protein length

From: Complete genome sequence of Treponema pallidum ssp. pallidumstrain SS14 determined with oligonucleotide arrays

ORFa

SNPs

Other changes

Result of mutation

Protein function

TP0006

1

read-through stop codon

longer protein (+262 aa), fusion with TP0007

Tp75 protein (possible surface protein)

TP0127

0

1 deletion (2 nt)

frameshift (-103 aa)

hypothetical protein

TP0132

0

1 insertion (1 nt)

frameshift (-44 aa)

hypothetical protein

TP0433–TP0434

1

insertion of tandem repeats

fusion of 2 ORFs (604 aa)

hypothetical proteins (resulting fusion – arp proteinc)

TP0468–TP0469

0

1 insertion (2 nt)

1 deletion (1 nt)

fusion of 2 ORFs (650 aa)

conserved hypothetical proteins

TP0470

0

deletion of 7 tandem repeats (7 × 24 nt)

shorter protein (-56 aa)

conserved hypothetical protein

TP0486

0

1 deletion (1 nt)b

frameshift (+9 aa)

antigen, p83/100 (possible surface protein)

TP0598

1

4 insertion (4 nt)b

frameshift (+81 aa) fusion with TP0597

hypothetical protein

TP0868

0

1 deletion (7 nt)

frameshift (-168aa)

flagellar filament 34.5 kDa core protein (FlaB1)

TP0924

1

nonsense mutation

shorter protein (-250 aa)

Tex protein

TP1030

7

1 insertion (1 nt)

frameshift (-46 aa)

hypothetical protein

  1. ORF – open reading frame; SNP – single nucleotide polymorphism; aa – amino acid; aas described in [3]; bsame sequence change detected in Nichols Houston strain genomic DNA; c same sequence change described in [19].