Table 1 Genes downregulated upon a temperature shift from 37°C to 25°C.

Energy production and conversion

RT0261

Complex III (mitochondrial electron transport). [Rickettsia typhi str. Wilmington]

0.5 (0.2, 0.6, 0.9)

RT0345

NADH dehydrogenase beta subunit [Rickettsia typhi str. Wilmington]

0.6 (0.5, 0.6, 0.7)

RT0171

2-oxoglutarate dehydrogenase (lipoamide) E1 component [Rickettsia typhi str. Wilmington]

0.7 (0.5, 0.7, 0.6)

Cell cycle control, mitosis and meiosis

RT0380

putative intracellular septation protein [Rickettsia typhi str. Wilmington]

0.6 (0.4, 0.9, 0.6)

Amino acid transport and metabolism

RT0297

AtrC1-like cationic amino acid transporter protein [Rickettsia typhi str. Wilmington]

0.6 (0.3, 0.6, 1.8)

RT0473

cysteine desulfurase [Rickettsia typhi str. Wilmington]

0.6 (0.7, 0.7, 0.5)

RT0118

glutamine transport system permease protein GlnP [Rickettsia typhi str. Wilmington]

0.6 (0.3, 0.9, 0.4)

RT0474

cysteine desulfurase protein IscS/NifS [Rickettsia typhi str. Wilmington]

0.6 (0.4, 0.9, 0.6)

Nucleotide transport and metabolism

RT0498

ribonucleotide-diphosphate reductase alpha subunit [Rickettsia typhi str. Wilmington]

0.4 (0.4, 0.4, 0.5)

Carbohydrate transport and metabolism

RT0479

hypothetical protein RT0479 [Rickettsia typhi str. Wilmington]

0.6 (0.6, 0.5, 0.6)

RT0290

ribose-5-phosphate isomerase B [Rickettsia typhi str. Wilmington]

0.6 (1.1, 0.6, 0.3)

Coenzyme transport and metabolism

RT0829

5-aminolevulinate synthase [Rickettsia typhi str. Wilmington]

0.5 (0.2, 0.5, 0.8)

RT0501

methylenetetrahydrofolate dehydrogenase (NADP+) [Rickettsia typhi str. Wilmington]

0.7 (0.6, 0.7, 0.6)

Translation

RT0638

30S ribosomal protein S14 [Rickettsia typhi str. Wilmington]

0.5 (0.7, 0.6, 0.3)

RT0812

methionine aminopeptidase [Rickettsia typhi str. Wilmington]

0.5 (0.6, 0.5, 0.4)

RT0645

30S ribosomal protein S3 [Rickettsia typhi str. Wilmington]

0.5 (0.5, 0.6, 0.4)

RT0653

elongation factor Tu [Rickettsia typhi str. Wilmington]

0.5 (0.3, 0.6, 0.6)

RT0644

50S ribosomal protein L16 [Rickettsia typhi str. Wilmington]

0.5 (0.6, 0.5, 0.5)

RT0140

aspartyl/glutamyl-tRNA amidotransferase subunit B [Rickettsia typhi str. Wilmington]

0.5 (1.4, 0.4, 0.4)

RT0642

30S ribosomal protein S17 [Rickettsia typhi str. Wilmington]

0.6 (0.8, 0.6, 0.4)

RT0648

50S ribosomal protein L2 [Rickettsia typhi str. Wilmington]

0.6 (0.6, 0.7, 0.6)

RT0316

glutamyl-tRNA synthetase [Rickettsia typhi str. Wilmington]

0.6 (0.5, 0.8, 0.6)

RT0372

prolyl-tRNA synthetase [Rickettsia typhi str. Wilmington]

0.7 (0.4, 0.7, 0.9)

RT0606

isoleucyl-tRNA synthetase [Rickettsia typhi str. Wilmington]

0.7 (0.4, 0.8, 0.7)

Transcription

RT0129

DNA-directed RNA polymerase beta subunit [Rickettsia typhi str. Wilmington]

0.5 (0.3, 0.5, 0.8)

RT0130

DNA-directed RNA polymerase beta' subunit [Rickettsia typhi str. Wilmington]

0.7 (0.6, 0.6, 0.9)

RT0152

transcription antitermination protein NusB [Rickettsia typhi str. Wilmington]

0.7 (0.6, 0.7, 0.6)

RT0061

transcriptional activator protein CzcR [Rickettsia typhi str. Wilmington]

0.6 (0.5, 0.7, 0.6)

Replication, recombination and repair

RT0706

DNA ligase [Rickettsia typhi str. Wilmington]

0.4 (0.3, 0.3, 0.6)

RT0228*

dinucleoside polyphosphate hydrolase [Rickettsia typhi str. Wilmington]

0.5 (0.5, 0.5, 0.4)

RT0805

tyrosine recombinase [Rickettsia typhi str. Wilmington]

0.6 (0.7, 0.6, 0.6)

Cell wall/membrane biogenesis

RT0393*

hypothetical protein RT0393 [Rickettsia typhi str. Wilmington]

0.6 (0.6, 0.6, 0.6)

RT0326

probable glycosyltransferase [Rickettsia typhi str. Wilmington]

0.7 (0.6, 0.8, 0.4)

Posttranslational modification, protein turnover, chaperones

RT0319*

hypothetical protein RT0319 [Rickettsia typhi str. Wilmington]

0.5 (0.3, 0.6, 0.3)

RT0617

chaperonin GroEL [Rickettsia typhi str. Wilmington]

0.5 (0.4, 0.4, 1.0)

RT0191

co-chaperone HscB [Rickettsia typhi str. Wilmington]

0.5 (0.7, 0.7, 0.2)

RT0828*

heat shock protein 90 [Rickettsia typhi str. Wilmington]

0.5 (0.3, 0.6, 0.5)

RT0318

thioredoxin peroxidase I [Rickettsia typhi str. Wilmington]

0.5 (0.6, 0.8, 0.4)

RT0111

protease activity modulator protein HflK [Rickettsia typhi str. Wilmington]

0.6 (0.8, 0.4, 0.6)

RT0476

Glutathione S-alkyltransferase. [Rickettsia typhi str. Wilmington]

0.6 (0.2, 0.7, 1.1)

RT0618*

co-chaperonin GroES [Rickettsia typhi str. Wilmington]

0.6 (0.5, 0.5, 0.7)

RT0176

molecular chaperone DnaK [Rickettsia typhi str. Wilmington]

0.6 (0.4, 0.6, 1.1)

Inorganic ion transport and metabolism

RT0612

zinc/manganese ABC transporter permease protein [Rickettsia typhi str. Wilmington]

0.6 (0.3, 1.1, 0.6)

RT0258

hypothetical protein RT0258 [Rickettsia typhi str. Wilmington]

0.6 (0.5, 0.9, 0.6)

General function prediction only

RT0320*

hypothetical protein RT0320 [Rickettsia typhi str. Wilmington]

0.6 (0.5, 0.5, 0.6)

RT0431

hypothetical protein RT0431 [Rickettsia typhi str. Wilmington]

0.6 (0.4, 0.6, 1.2)

RT0035

GTP-binding protein [Rickettsia typhi str. Wilmington]

0.6 (0.3, 0.9, 1.2)

Function unknown

RT0471

iron-binding protein IscA/HesB [Rickettsia typhi str. Wilmington]

0.5 (0.4, 0.7, 0.6)

RT0519*

rickettsial conserved hypothetical protein [Rickettsia typhi str. Wilmington]

0.6 (0.7, 0.7, 0.4)

Signal transduction mechanism

RT0550

nitrogen assimilation regulatory protein NtrX [Rickettsia typhi str. Wilmington]

0.6 (0.5, 0.7, 0.6)

not in COG database

RT0259

heme exporter protein B [Rickettsia typhi str. Wilmington]

0.5 (0.6, 0.8, 0.3)

RT0077*

nucleoside diphosphate kinase [Rickettsia typhi str. Wilmington]

0.5 (0.6, 0.5, 0.5)

RT0874

coproporphyrinogen III oxidase [Rickettsia typhi str. Wilmington]

0.5 (0.7, 0.7, 0.3)

RT0325*

rickettsial conserved hypothetical protein [Rickettsia typhi str. Wilmington]

0.6 (0.6, 0.8, 0.4)

RT0426

rickettsial conserved hypothetical protein [Rickettsia typhi str. Wilmington]

0.6 (0.2, 0.6, 1.5)

RT0485

cell surface antigen [Rickettsia typhi str. Wilmington]

0.6 (1.1, 0.7, 0.2)

RT0686

rickettsial conserved hypothetical protein [Rickettsia typhi str. Wilmington]

0.6 (0.7, 0.6, 0.5)

RT0126

50S ribosomal protein L1 [Rickettsia typhi str. Wilmington]

0.6 (0.6, 1.0, 0.6)

RT0102

hypothetical protein RT0102 [Rickettsia typhi str. Wilmington]

0.6 (0.6, 0.8, 0.5)

RT0701

possible beta-glucosidase [Rickettsia typhi str. Wilmington]

0.6 (0.8, 0.6, 0.5)