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Figure 6 | BMC Microbiology

Figure 6

From: Limited functional conservation of a global regulator among related bacterial genera: Lrp in Escherichia, Proteus and Vibrio

Figure 6

Statistical tests for significance of microarray results. For details, see text. A. Generating a NULL distribution of overlaps by randomly swapping columns of ratio values between two sets for the data that were used to generate Figs. 5 and 7. For each gene in a comparison between (for example) the E. coli and V. cholerae Lrps, there are three ratios (R1–3) for LrpK12 and three for LrpVch. The first three ratios are from the triplicate experiments in which the lrp null E. coli strain was complemented with a plasmid carrying the E. coli lrp+ gene (LrpK12/lrp), and the second three ratios are from the complementations with V. cholerae lrp (LrpVch/lrp). B. Comparison of the fractions of genes differentially regulated (directly or indirectly) by both Lrps in pairwise comparisons. The analysis was carried out using different ratio cut-offs, among the sets presented in Fig. 7. Fractions were calculated as the number of common genes in two sets (having an expression ratio above a given limit), divided by the total number of unique genes in both sets (above the same limit).

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