AI-2-dependent gene regulation in Staphylococcus epidermidis

Li, Min; Villaruz, Amer E; Vadyvaloo, Viveka; Sturdevant, Daniel E; Otto, Michael

doi:10.1186/1471-2180-8-4

BMC Microbiology

Table 2 Gene regulatory responses in S. epidermidis wild-type, ΔluxS and ΔluxS with exogenous AI-2

From: AI-2-dependent gene regulation in Staphylococcus epidermidis

Gene number	Gene product	ΔluxS/WT	ΔluxS+ AI-2/ΔluxS
	Glycometabolism
SE0164	Hexose phosphate transport protein	0.46	4.82
SE1219	Truncated transposase	2.41	0.44
SERP1353	Phosphoenolpyruvate carboxykinase	0.3	6.43
SERP1791	PTS system, lactose-specific IIA component	0.52	2.15
SERP1792	Tagatose 1,6-diphosphate aldolase	0.45	2.23
SERP1793	Tagatose-6-phosphate kinase	0.41	2.47
SERP1794	Galactose-6-phosphate isomerase	0.4	2.45
SERP1795	Galactose-6-phosphate isomerase	0.42	2.48
SERP1909	PTS system, IIBC components	0.37	3.88
SERP2057	Gluconate transporter, permease protein	0.48	3.94
SERP2058	Gluconokinase	0.33	6.43
SERP2059	Gluconate operon transcriptional repressor	0.37	6.03
SERP2100	Ribokinase	0.49	2.71
SERP2101	Ribose transport protein	0.42	3.14
SERP2260	PTS system, fructose-specific IIABC components	0.29	8.11
SERP2261	Mannose-6-phosphate isomerase	0.34	5.9
SERP2312	Malate:quinone oxidoreductase	2.64	0.33
	Nucleotide metabolism
SERP0067	Xanthine phosphoribosyltransferase	3.17	0.4
SERP0068	Xanthine permease	3.35	0.39
SERP0652	Phosphoribosylformylglycinamidine synthase, PurS protein	3.65	0.45
SERP0653	Phosphoribosylformylglycinamidine synthase I	3.84	0.37
SERP0654	Phosphoribosylformylglycinamidine synthase II	3.17	0.4
SERP0655	Amidophosphoribosyltransferase	3.68	0.26
SERP0656	Phosphoribosylaminoimidazole synthetase	2.62	0.33
SERP0657	Phosphoribosylglycinamide formyltransferase	2.52	0.35
SERP0658	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	2.45	0.34
SERP0659	Phosphoribosylamine – glycine ligase	2.21	0.42
	Amino acid metabolism
SERP2128	Delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.42	3.2
SERP2327	Acetoin dehydrogenase, E3 component, dihydrolipoamide dehydrogenase	0.49	6.18
SERP2326	Acetoin dehydrogenase, E1 component, alpha subunit	0.44	5.24
SERP2325	Acetoin dehydrogenase, E1 component, beta subunit	0.53	4.95
	Nitrogen metabolism
SERP1980	Nitrite extrusion protein	3.16	0.28
SERP1984	Respiratory nitrate reductase, gamma subunit	2.57	0.47
SERP1985	Respiratory nitrate reductase, delta subunit	4.81	0.39
SERP1986	Respiratory nitrate reductase, beta subunit	3.93	0.47
SERP1989	Nitrite reductase	2.52	0.46
	Other
SERP0878	Portal protein, truncation	3.76	0.48
SERP2027	Antiholin-like protein LrgB	0.46	9.38
SERP2069	Major facilitator superfamily protein	0.5	2.36
SERP2222	Transcriptional regulator CadC	2.09	0.48
	Unclassified
SERP0895	Hypothetical protein	0.36	3.53
SERP1923	Hypothetical protein	2.27	0.43
SERP2068	Hypothetical protein	0.45	3.99
SERP2102	Hypothetical protein	0.37	3.84
SERP2333	Hypothetical protein	0.53	2.55

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ISSN: 1471-2180

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