Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia

Table 1 Study isolates and susceptibility results

Isolate	Phenotype^a	MIC^b(μg/ml)		Reference or Comment
		VCM	TEIC
Pair 1
JKD 6000	VSSA	2.0	0.5	[12]
JKD 6001	VISA	4.0	8.0	[12]
Pair 2
JKD 6009	VSSA	1.0	0.5	[12]
JKD 6008	VISA	4.0	2.0	[12]
Pair 3
JKD 6021	VSSA	1.0	0.25	[12]
JKD 6023	VISA	4.0	8.0	[12]
Pair 4
JKD 6052	VSSA	1.0	0.5	[12]
JKD 6051	hVISA	2.0	4.0	[12]
Pair 5
JKD 6004	VSSA	1.0	0.5	[12]
JKD 6005	hVISA	2.0	4.0	[12]
Pair 6 (control)
JKD 6084	VSSA	0.5	≤ 0.25	[this study]
JKD 6089	VSSA	1.0	≤ 0.25	[this study]
Pair 7 (control)
JKD 6090	VSSA	0.5	≤ 0.25	[this study]
JKD 6094	VSSA	0.5	≤ 0.25	[this study]
Pair 8 (control)
JKD 6095	VSSA	1.0	0.5	[this study]
JKD 6097	VSSA	1.0	0.5	[this study]
Other Isolates
P1				Cap8 positive [57]
Newman				Cap5 positive [57]

^aVSSA, vancomycin-susceptible S. aureus; VISA, vancomycin-intermediate S. aureus; hVISA, hetero-VISA.
^bMinimum inhibitory concentration. VCM, vancomycin; TEIC, teicoplanin.