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Table 1 Summary of findings

From: Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-γ ELISPOT tests following a tuberculosis outbreak

TST status Baboon number IFN-γ ELISPOT (SFC/106 PBMC)# Pathology (lungs and BLN) Special staining Mycobacteria culture
   PPD ESAT6 CFP10 Necropsy Histopathology ZN MT IP  
TST positive baboons B454Ψ 902 774 157 Negative No granulomas; mild interstitial lymphocytic infiltration in BLN + (BLN only) Negative Negative
  B524 2650 2163 2243 Several tubercles; caseous LN Multifocal necrogranulomas Negative + M. tuberculosis
  B531 210 89 109 Several tubercles; caseous LN Multifocal necrogranulomas; caseous necrosis in BLN + + M. tuberculosis
  B536Ψ 743 20 11 Negative No granulomas; mild peribronchial fibrosis; + Negative Negative
  B548Ψ ND ND ND Negative ND ND ND Negative
  B629 736 448 1348 Several tubercles; caseous LN Multifocal necrogranulomas + Negative M. tuberculosis
  B659 ND ND ND Single tubercle; single caseous LN ND ND ND M. tuberculosis
  B697 1748 0 0 A single tubercle-like lesion; enlarged hilar LN Multifocal areas of granulomatous pneumonia Negative Negative Negative
  B369* 1397 1192 1170 Negative No granumomas; focal hyperplasia in BLN Negative Negative M. intracellulare
TST negative baboons B630 0 35 48 Negative No granulomas; mild lymphatic hyperplasia in BLN Negative Negative Negative
  B673 ND ND ND Single caseous LN Multifocal mild pneumonitis + + M. tuberculosis
  B679 0 67 109 Negative No granulomas; mild multifocal perivascular lymphocytic cuffing Negative Negative Negative
  B689 78 117 63 Negative Negative Negative Negative Negative
  B694 0 86 66 Negative Mild granulomatous inflammation Negative Negative M. intracellulare
  B696 0 69 17 Negative Negative Negative Negative Negative
  B704 2 28 33 Negative Negative Negative Negative Negative
  B709 50 60 138 Negative Negative Negative Negative M. intracellulare
  1. This table gives a summary of the major findings of the study. ND: not determined; BLN: bronchial lymph node; +: positive outcome; *: initially TST negative; Ψ: known prior vaccination with BCG or recombinant BCG; #: cut-off values for PPD, ESAT-6 & CFP-10 = 86, 70, & 60 SFC/106 respectively (bold face indicate a positive response).
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BMC Microbiology

ISSN: 1471-2180

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