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Table 4 Time kill curve against β-lactamase positive H. influenzae (n = 50)

From: In vitro activity of telithromycin against Haemophilus influenzae at epithelial lining fluid concentrations

Antibiotic   Changes in colony counts vs initial inocula after
   3 h 6 h 12 h 24 h
   CO2 Air CO2 Air CO2 Air CO2 Air
Telithromycin 4 × MIC -1.28 -1.44 -2.74 -2.80 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -0.37 -0.89 -1.57 -1.77 -2.77 -2.88 > -3.0 > -3.0
  1 × MIC -0.53 -0.16 -0.82 -0.76 -0.96 -1.12 -1.51 -1.62
  1/2 × MIC -0.13 -0.04 1.06 0.13 1.33 1.61 3.59 2.08
  1/4 × MIC 0.33 0.41 1.66 1.29 2.46 2.74 4.03 3.19
  ELF -1.00 -0.96 -2.68 -2.72 > -3.0 > -3.0 > -3.0 > -3.0
Clarithromycin 4 × MIC -1.47 -0.88 -2.00 -2.22 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -0.80 -0.30 -1.14 -1.51 -1.42 -1.86 > -3.0 > -3.0
  1 × MIC -0.27 -0.06 -0.79 -0.60 -1.31 -1.61 -1.40 -1.86
  1/2 × MIC 0.52 0.45 2.43 2.42 2.36 2.38 2.63 2.84
  1/4 × MIC 0.71 0.69 2.69 2.47 2.73 3.25 3.91 3.98
  ELF -0.91 -1.22 -2.65 > -3.0 > -3.0 > -3.0 > -3.0 > -3.0
Azithromycin 4 × MIC -1.49 -2.22 -2.61 -2.85 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -0.98 -1.68 -1.65 -1.93 > -3.0 > -3.0 > -3.0 > -3.0
  1 × MIC -1.03 -0.64 -1.23 -0.48 -1.43 -0.68 -1.62 -0.23
  1/2 × MIC -0.67 -0.15 -0.03 1.86 0.47 1.93 3.67 2.18
  1/4 × MIC 0.29 0.26 1.58 1.96 2.34 2.13 4.12 3.28
  ELF -1.05 -1.20 -2.27 -2.53 > -3.0 > -3.0 > -3.0 > -3.0
Control   0.62 0.73 2.38 2.49 4.02 4.13 4.44 4.55