Table 4 Time kill curve against β-lactamase positive H. influenzae (n = 50)
Antibiotic | Â | Changes in colony counts vs initial inocula after | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | 3 h | 6 h | 12 h | 24 h | ||||
| Â | Â | CO2 | Air | CO2 | Air | CO2 | Air | CO2 | Air |
Telithromycin | 4 × MIC | -1.28 | -1.44 | -2.74 | -2.80 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
|  | 2 × MIC | -0.37 | -0.89 | -1.57 | -1.77 | -2.77 | -2.88 | > -3.0 | > -3.0 |
|  | 1 × MIC | -0.53 | -0.16 | -0.82 | -0.76 | -0.96 | -1.12 | -1.51 | -1.62 |
|  | 1/2 × MIC | -0.13 | -0.04 | 1.06 | 0.13 | 1.33 | 1.61 | 3.59 | 2.08 |
|  | 1/4 × MIC | 0.33 | 0.41 | 1.66 | 1.29 | 2.46 | 2.74 | 4.03 | 3.19 |
| Â | ELF | -1.00 | -0.96 | -2.68 | -2.72 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
Clarithromycin | 4 × MIC | -1.47 | -0.88 | -2.00 | -2.22 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
|  | 2 × MIC | -0.80 | -0.30 | -1.14 | -1.51 | -1.42 | -1.86 | > -3.0 | > -3.0 |
|  | 1 × MIC | -0.27 | -0.06 | -0.79 | -0.60 | -1.31 | -1.61 | -1.40 | -1.86 |
|  | 1/2 × MIC | 0.52 | 0.45 | 2.43 | 2.42 | 2.36 | 2.38 | 2.63 | 2.84 |
|  | 1/4 × MIC | 0.71 | 0.69 | 2.69 | 2.47 | 2.73 | 3.25 | 3.91 | 3.98 |
| Â | ELF | -0.91 | -1.22 | -2.65 | > -3.0 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
Azithromycin | 4 × MIC | -1.49 | -2.22 | -2.61 | -2.85 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
|  | 2 × MIC | -0.98 | -1.68 | -1.65 | -1.93 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
|  | 1 × MIC | -1.03 | -0.64 | -1.23 | -0.48 | -1.43 | -0.68 | -1.62 | -0.23 |
|  | 1/2 × MIC | -0.67 | -0.15 | -0.03 | 1.86 | 0.47 | 1.93 | 3.67 | 2.18 |
|  | 1/4 × MIC | 0.29 | 0.26 | 1.58 | 1.96 | 2.34 | 2.13 | 4.12 | 3.28 |
| Â | ELF | -1.05 | -1.20 | -2.27 | -2.53 | > -3.0 | > -3.0 | > -3.0 | > -3.0 |
Control | Â | 0.62 | 0.73 | 2.38 | 2.49 | 4.02 | 4.13 | 4.44 | 4.55 |